ArticleEnvironment & health (Washington, D.C.)2023
Bisphenol AF Induces Alterations in the Plasma Lipidome of Rats: An Untargeted Lipidomics Approach.
Article in Environment & health (Washington, D.C.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol AF has gained popularity as a substitute for bisphenol A in industrial applications, leading to its detection in various biological fluids and raising concerns for public health. While the effects of bisphenol A on lipid metabolism are known, the impact of bisphenol AF on different lipid classes remains understudied. This study aimed to address this gap by conducting an untargeted lipidomics analysis in rats to assess the influence of bisphenol AF on lipid homeostasis. The results of the study revealed significant alterations in lipid profiles in plasma with various lipid classes being affected by bisphenol AF exposure. High-dose exposure to bisphenol AF resulted in specific changes within lipid clusters, including a decrease in the fatty acyl lipid cluster, except for 3,6,9,12,15-octadecapentaenoic acid. Additionally, the compound 9-0-acetyl GTb1(d18:1/18:0) within the gangliosides subclass of the sphingolipids and the sterol lipid clusters was also affected. These findings contribute to a better understanding of how bisphenol AF disrupts lipid metabolism and its associated health effects. This study provides valuable insights into the potential risks posed by bisphenol AF. Further research in this area is warranted to explore the mechanisms underlying the bisphenol AF-induced dysregulation of lipid metabolism and its implications for human health.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.