ArticleWorld journal of psychiatry2024
Bidirectional relationship between diabetes mellitus and depression: Mechanisms and epidemiology.
Article in World journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of the selective serotonin reuptake inhibitors citalopram and escitalopram on glucolipid metabolism: a systematic review.Frontiers in endocrinology · 2025Pooled it
- National and subnational burden of mental disorders in China, 1990-2023: a systematic analysis of the Global Burden of Disease Study 2023.The Lancet regional health. Western Pacific · 2026Article
- Joint Association of Functional Impairment and Depression with Advanced Cardiovascular-Kidney-Metabolic Syndrome: A Cross-Sectional and Cohort Study Using Two Large Datasets.Healthcare (Basel, Switzerland) · 2026Article
- [Mental and neurocognitive diseases and diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Association of metabolic syndrome with comorbid major depressive disorder in remitted schizophrenia: a cross-sectional study.BMC psychiatry · 2026Article
- Age and sex differences in diabetic ketoacidosis outcomes in type 1 diabetes: a national cohort study.BMJ open diabetes research & care · 2026Article
- Prevalence and associated factors of depression and anxiety in Saudi adults with type 1 diabetes: a cross-sectional study.Scientific reports · 2026Article
- Neuroprotective effects of low-dose ionizing radiation in diabetic rats exposed to chronic unpredictable stress.Journal of advanced veterinary and animal research · 2026Article
- Mechanisms of interaction between type 2 diabetes and psychological disorders and therapeutic interventions: a narrative review.Frontiers in medicine · 2026Review
- Article
- Depression and its Association With Cataract Status and Self-Perceived Burden of Elderly Patients With Cataract.Actas espanolas de psiquiatria · 2025Article
- Systemic Inflammation at the Crossroad of Major Depressive Disorder and Comorbidities: A Narrative Review.International journal of molecular sciences · 2025Review
- Does the Interaction Between Alcohol Use and Depression Exacerbate Hyperglycemia Risk? A Cross-Sectional Study Beyond Additive Effects.Medicina (Kaunas, Lithuania) · 2025Article
- Breaking the diabetes-depression cycle: Exploring shared mechanisms, neuroinflammation, and emerging interventions for metabolic-mood comorbidities.World journal of diabetes · 2025Article
- Effects of depression and suicidal ideation on health-related quality of life in diabetic individuals: findings from a population-based study.Diabetology & metabolic syndrome · 2025Article
- Prevalence and impact of microvascular complications in type 2 diabetes mellitus on cognitive impairment and depression: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2025Review
- Development and validation of a nomogram for predicting depression risk in patients with chronic kidney disease based on NHANES 2005-2018.Journal of health, population, and nutrition · 2025Article
- Association between Geriatric Nutrition Risk Index and depression in older hemodialysis patients with and without type 2 diabetes mellitus: a multicenter cross-sectional study.Frontiers in endocrinology · 2025Article
- Prospective longitudinal study of dynamic depressive symptom trajectories and diabetes onset risk in older adults: a 10-year follow-up of the HRS and ELSA cohorts.Frontiers in public health · 2025Article
- Prevalence and associated factors of depressive symptoms among older adult diabetic patients in China: a nationally representative cross-sectional study.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus and depression exhibit a complex bidirectional relationship that profoundly impacts patient health and quality of life. This review explores the physiological mechanisms, including inflammation, oxidative stress, and neuroendocrine dysregulation, that link these conditions. Psychosocial factors such as social support and lifestyle choices also contribute significantly. Epidemiological insights reveal a higher prevalence of depression among diabetics and an increased risk of diabetes in depressed individuals, influenced by demographic variables. Integrated management strategies combining mental health assessments and personalized treatments are essential. Future research should focus on longitudinal and multi-omics studies to deepen understanding and improve therapeutic outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.