Evidence map›Paper›PMID 39475214›Full record

SynthesisCancer biology & medicine2024

Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review.

Xiaoning Gan, Guanqi Dai, Yonghao Li, Lin Xu, Guolong Liu

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer biology & medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Study of Estrogen Receptor Alpha Gene Polymorphisms (International journal of molecular sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoning Gan *Department of Medical Oncology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.
Guanqi Dai *Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yonghao LiDepartment of Medical Oncology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.
Lin XuDepartment of Medical Oncology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.
Guolong LiuDepartment of Medical Oncology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID 0000-0002-8336-1703

Funding

Key Project of Scientific and Technologic Bureau of Guangzhou City 202201020335Project of Scientific and Technologic Bureau of Guangzhou City 202201010165
6 · The paper itself

Abstract

Gender disparities are evident across different types of digestive system cancers, which are typically characterized by a lower incidence and mortality rate in females compared to males. This finding suggests a potential protective role of female steroid hormones, particularly estrogen, in the development of these cancers. Estrogen is a well-known sex hormone that not only regulates the reproductive system but also exerts diverse effects on non-reproductive organs mediated through interactions with estrogen receptors (ERs), including the classic (ERα and ERβ) and non-traditional ERs [G protein-coupled estrogen receptor (GPER)]. Recent advances have contributed to our comprehension of the mechanisms underlying ERs in digestive system cancers. In this comprehensive review we summarize the current understanding of the intricate roles played by estrogen and ERs in the major types of digestive system cancers, including hepatocellular, pancreatic, esophageal, gastric, and colorectal carcinoma. Furthermore, we discuss the potential molecular mechanisms underlying ERα, ERβ, and GPER effects, and propose perspectives on innovative therapies and preventive measures targeting the pathways regulated by estrogen and ERs. The roles of estrogen and ERs in digestive system cancers are complicated and depend on the cell type and tissue involved. Additionally, deciphering the intricate roles of estrogen, ERs, and the associated signaling pathways may guide the discovery of novel and tailored therapeutic and preventive strategies for digestive system cancers, eventually improving the care and clinical outcomes for the substantial number of individuals worldwide affected by these malignancies.

Indexed as

Digestive System NeoplasmsEstrogensReceptors, EstrogenAnimalsEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansMaleReceptors, G-Protein-CoupledSignal TransductionEstrogen Receptor alphaEstrogen Receptor betaEstrogensReceptors, EstrogenReceptors, G-Protein-Coupledcancerdigestive system cancersEstrogenestrogen receptorgender disparity

Identifiers

PMID39475214
PMCPMC11523274

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.