Evidence map›Paper›PMID 39475550›Full record

ArticleACS infectious diseases2024

Improved Broad Spectrum Antifungal Drug Synergies with Cryptomycin, a Cdc50-Inspired Antifungal Peptide.

Robert J Tancer, Siddhi Pawar, Yina Wang, Cristina R Ventura, Gregory Wiedman, Chaoyang Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert J TancerPublic Health Research Institute and Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103, United States.
Siddhi PawarPublic Health Research Institute and Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103, United States.
Yina WangPublic Health Research Institute and Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103, United States.
Cristina R VenturaDepartment of Chemistry and Biochemistry, Seton Hall University, South Orange, New Jersey 07079, United States.
Gregory WiedmanDepartment of Chemistry and Biochemistry, Seton Hall University, South Orange, New Jersey 07079, United States.ORCID 0000-0002-6720-699X
Chaoyang XuePublic Health Research Institute and Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103, United States.

Funding

The role of inositol in Cryptococcus biology and pathogenesisR01AI123315 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Chaoyang Xue · 2017 to 2026
$5.0M
Trained immunity and the regulation of anti-fungal defenseR01AI169769 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Amariliz Rivera, Chaoyang Xue · 2022 to 2026
$3.1M
Role of phospholipids in antifungal drug resistance in Cryptococcus neoformansR01AI155647 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Chaoyang Xue · 2022 to 2026
$2.8M
NIAID NIH HHS R01 AI123315NIAID NIH HHS R01 AI155647NIAID NIH HHS R01 AI169769
6 · The paper itself

Abstract

Fungal infections in humans are difficult to treat, with very limited drug options. Due to a confluence of factors, there is an urgent need for innovation in the antifungal drug space, particularly to combat increasing antifungal drug resistance. Our previous studies showed that Cdc50, a subunit of fungal lipid translocase (flippase), is essential for

Indexed as

Antifungal AgentsCryptococcus neoformansDrug SynergismMicrobial Sensitivity TestsAnimalsAspergillus fumigatusCandidaCandida albicansDrug Resistance, FungalFungal ProteinsHumansMicePeptidesPhospholipid Transfer ProteinsReactive Oxygen SpeciesAntifungal AgentsFungal ProteinsPeptidesPhospholipid Transfer ProteinsReactive Oxygen Speciesantifungal peptidecdc50drug resistancelipid flippasepathogenic fungi

Identifiers

PMID39475550
PMCPMC11555678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.