Evidence map›Paper›PMID 39475605›Full record

ArticleScience advances2024

A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings.

Pedro J Del Rivero Morfin, Diego Scala Chavez, Srinidhi Jayaraman, Lin Yang, Stefanie M Geisler, Audrey L Kochiss, Petronel Tuluc, Henry M Colecraft, Steven O Marx, X Shawn Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Astrocytic abnormalities in brain-specificChannels (Austin, Tex.) · 2025
    Article
  2. The CaInternational journal of molecular sciences · 2025
    Review
  3. Modulating ion channels with nanobodies.Synthetic and systems biotechnology · 2025
    Review
  4. Probing the CabioRxiv : the preprint server for biology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Pedro J Del Rivero MorfinDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-8554-145X
Diego Scala ChavezPediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Srinidhi JayaramanDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Lin YangDivision of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Stefanie M GeislerDepartment of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Tyrol, Austria.ORCID 0000-0002-8898-0108
Audrey L KochissDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Petronel TulucDepartment of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Tyrol, Austria.ORCID 0000-0003-3660-6138
Henry M ColecraftDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-2340-8899
Steven O MarxDivision of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
X Shawn LiuDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-2799-2519
Anjali M RajadhyakshaPediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8399-5466
Manu Ben-JohnyDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-5645-0815

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Structure-Function of Calcium Channel Complexes in Cardiac Physiology and DiseaseP01HL164319 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Henry M. Colecraft · 2023 to 2026
$12.1M
Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid CrosstalkR01DA054368 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Francis Sang Yong Lee, Anjali M Rajadhyaksha · 2022 to 2026
$3.5M
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memoriesR01DA053261 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Anjali M Rajadhyaksha · 2022 to 2026
$2.6M
GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum DisordersR01MH125006 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA, RAJADHYAKSHA, ANJALI M · 2021 to 2025
$2.1M
Tuning of CaV channel dynamics by stac proteinsR01NS110672 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHNY, MANU BEN · 2019 to 2023
$1.7M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
NCI NIH HHS P30 CA013696NCRR NIH HHS S10 RR027050NHLBI NIH HHS P01 HL164319NIDA NIH HHS R01 DA053261NIDA NIH HHS R01 DA054368NIMH NIH HHS R01 MH125006NINDS NIH HHS R01 NS110672
6 · The paper itself

Abstract

L-type Ca

Indexed as

Calcium Channels, L-TypeMyocytes, CardiacAnimalsCalciumHEK293 CellsHumansMiceNeuronsCalciumCalcium Channels, L-Type

Identifiers

PMID39475605
PMCPMC11524184

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.