Evidence map›Paper›PMID 39476070›Full record

ArticleActa cirurgica brasileira2024

Melatonin associated with bacterial cellulose-based hydrogel improves healing of skin wounds in diabetic rats.

Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Érique Ricardo Alves, Glícia Maria de Oliveira, Anderson Arnaldo da Silva, Flávia Cristina Morone Pinto, José Lamartine de Andrade Aguiar, Diego Neves Araújo, Valéria Wanderley Teixeira, Álvaro Aguiar Coelho Teixeira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jaiurte Gomes Martins da SilvaUniversidade Federal Rural de Pernambuco - Department of Animal Morphology and Physiology - Graduate Program in Animal Bioscience - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0002-6310-1023
Ismaela Maria Ferreira de MeloUniversidade Federal Rural de Pernambuco - Department of Animal Morphology and Physiology - Graduate Program in Animal Bioscience - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0002-4150-1923
Érique Ricardo AlvesUniversidade Federal Rural de Pernambuco - Department of Animal Morphology and Physiology - Graduate Program in Animal Bioscience - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0002-7925-9212
Glícia Maria de OliveiraUniversidade Federal de Pernambuco - Department of Biochemistry - Graduate Program in Therapeutic Innovation - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0002-4415-5931
Anderson Arnaldo da SilvaUniversidade Federal de Pernambuco - Graduate Program in Biosciences and Biotechnology in Health - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0002-2727-6838
Flávia Cristina Morone PintoUniversidade Federal de Pernambuco - Department of Surgery - Graduate Program in Surgery - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0001-9196-7687
José Lamartine de Andrade AguiarUniversidade Federal de Pernambuco - Department of Surgery - Graduate Program in Surgery - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0003-4493-7359
Diego Neves AraújoUniversidade Federal de Alagoas - Maceió (AL) - Brazil.ORCID http://orcid.org/0000-0002-9541-5852
Valéria Wanderley TeixeiraUniversidade Federal Rural de Pernambuco - Department of Animal Morphology and Physiology - Graduate Program in Animal Bioscience - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0001-9533-5476
Álvaro Aguiar Coelho TeixeiraUniversidade Federal Rural de Pernambuco - Department of Animal Morphology and Physiology - Graduate Program in Animal Bioscience - Recife (PE) - Brazil.ORCID http://orcid.org/0000-0001-5940-9220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the effects of melatonin associated with bacterial cellulose-based hydrogel on healing of skin wounds in diabetic rats.

methodsStreptozotocin was used to induce diabetes in Wistar rats. After wound induction, animals were randomly divided into groups GC, GDCC, GDCB, and GDMCB. Animals were evaluated in days 3, 7, and 14 for the following variables: glycemic levels, histopathological and histochemical analyses, healing rate, morphometry and C-reactive protein.

resultsThere was no change in glycemic levels in the diabetic animals as a result of the treatments; histopathological analyses showed better healing in GDCB and GDMCB groups, as well as histochemistry; at day 14, the highest healing rate was observed in animals from the GDMCB group, reaching almost 100%; morphometry revealed a significant increase of fibroblasts and reduction of macrophages and blood vessels in lesions treated with bacterial cellulose associated or not with melatonin when compared to the other experimental groups. There was also an increase in C-reactive protein in GDCC group at day 14.

conclusionBacterial cellulose-based dressings associated with systemic melatonin showed beneficial results in experimentally induced wounds in diabetic rats, favoring the healing process.

Indexed as

CelluloseDiabetes Mellitus, ExperimentalMelatoninRats, WistarSkinWound HealingAnimalsAntioxidantsBlood GlucoseC-Reactive ProteinHydrogelsMaleRandom AllocationRatsReproducibility of ResultsTime FactorsAntioxidantsBlood GlucoseCelluloseC-Reactive ProteinHydrogelsMelatonin

Identifiers

PMID39476070
PMCPMC11506694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.