Evidence map›Paper›PMID 39476229›Full record

ArticleClinical and experimental nephrology2025

Comparative study of the protective effects of coenzyme Q10 and cinnamon extract on possible kidney damage and dysfunction of amiodarone in rats.

Ozgur Ekici, Abdullah Gul, Ercument Keskin, Seval Bulut, Bahadir Suleyman, Renad Mammadov, Betul Cicek, Ozlem Demir, Murat Gunay, Halis Suleyman

Abstract readComparative Study
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In one paragraph

Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ozgur EkiciDepartment of Urology, Bursa City Hospital, University of Health Sciences, Bursa, Turkey. ekici_1990@hotmail.com.
Abdullah GulDepartment of Urology, Bursa Higher Specialization Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
Ercument KeskinDepartment of Urology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Seval BulutDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Bahadir SuleymanDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Renad MammadovDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Betul CicekDepartment of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Ozlem DemirDepartment of Histology and Embryology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Murat GunayBiochemistry Laboratory, Erzincan Mengücek Gazi Training and Research Hospital, Erzincan Binali Yildirim University, Erzincan, Turkey.
Halis SuleymanDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn increase in free oxygen radicals and proinflammatory cytokines and decrease in intracellular adenosine triphosphate account for the nephrotoxic effect of amiodarone. This study investigated the protective effects of Coenzyme Q10 (CoQ10), cinnamon extract (CE) and the combination of the two (CoCE) on possible amiodarone-induced renal injury in rats.

methodsThirty male albino Wistar rats were cetegorized into healthy (HG), amiodarone (ADG), CoQ10 + amiodarone (CoQA), CE + amiodarone (CEA), and CoCE + amiodarone (CoCEA) groups. First, CoQ10 (10 mg/kg) and CE (100 mg/kg) were orally given. After 1 h, 50 mg/kg amiodarone was orally given to all groups except for HG. Amiodarone, CoQ10, and CE administration was continued orally at the indicated doses once daily for 10 days.Then, blood samples were collected from all groups to determine creatinine, blood urea nitrogen (BUN), and kidney injury molecule (KIM-1) levels, followed by euthanasia and removal of kidney tissues. Oxidative stress and inflammatory parameters were analysed in the tissue samples. Histopathological examination was also performed on the tissues.

resultsAmiodarone increased malondialdehyde levels and decreased total glutathione, superoxide dismutase, and catalase levels (p < 0.001). Amiodarone increased the expression and tissue levels of tissue nuclear factor kappa B, tumor necrosis factor-alpha, interleukin-1β and interleukin-6, and led to increases in serum creatinine and BUN and KIM-1 levels (p < 0.001). Amiodarone also caused histopathological damage (p < 0.001).CoQ10, CE and especially CoCE inhibited biochemical changes and tissue damage (p < 0.001).

conclusionAlthough CoQ10, CE, and CoCE effectively prevent amiodarone-induced oxidative and inflammatory nephrotoxicity, CoCE appears to be superior.

Indexed as

Acute Kidney InjuryAmiodaroneAntioxidantsCinnamomum zeylanicumKidneyKidney DiseasesPlant ExtractsUbiquinoneAnimalsBlood Urea NitrogenCell Adhesion MoleculesCreatinineMaleOxidative StressRatsRats, WistarAmiodaroneAntioxidantsCell Adhesion Moleculescoenzyme Q10CreatinineHavcr1 protein, ratPlant ExtractsUbiquinoneAntiarrhythmicAnti-inflammatoryAntioxidantNephrotoxicityProinflammatory cytokine

Identifiers

PMID39476229

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.