Evidence map›Paper›PMID 39476284›Full record

SynthesisHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2024

Effect of Phytosterols on Serum Levels of C-Reactive Protein: A Time- and Dose-Response Meta-analysis of Randomized Controlled Trial.

Saeed Aslani, Mohammad Masoud Eslami, Ghasem Fakourizad, Ahmad Faisal Faiz, Kayhan Mohammadi, Omid Dehghan, Danyal Imani, Alireza Abbaspour, Tannaz Jamialahmadi, Bahman Razi and 1 more

Abstract readMeta-AnalysisSystematic Review
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In one paragraph

Synthesis in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saeed AslaniCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Mohammad Masoud EslamiDepartment of Hematology and Blood Transfusion, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Ghasem FakourizadDepartment of Hematology and Transfusion Science, School of Allied medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
Ahmad Faisal FaizDepartment of Para Clinic, School of Medicine, Herat University, Herat, Afghanistan.
Kayhan MohammadiDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Omid DehghanTropical and Communicable Diseases Research Centre, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Danyal ImaniDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Alireza AbbaspourDepartment of Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Tannaz JamialahmadiPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Bahman RaziDepartment of Laboratory Sciences and Hematology, North Khorasan University of Medical Sciences, Bojnurd, Iran. razi_bahman@yahoo.com.
Amirhossein SahebkarCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospitals, Saveetha University, Chennai, India. amir_saheb2000@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPhytosterols are recognized for their cholesterol-reducing effects and are commonly used as dietary supplements or added to foods due to their potential cardiovascular benefits. However, evidence regarding the impact of phytosterol supplementation on inflammatory markers remains inconclusive.

aimThis systematic review and meta-analysis aim to evaluate the effect of phytosterols in reducing levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP).

methodsA systematic literature search of the primary databases was conducted up to May 2024 to identify eligible studies. The measurement of effect sizes was determined using WMD (weighted mean difference) and 95% CI.

resultsFor the meta-analysis, 14 publications (19 study arms) for hs-CRP and 10 publications (16 study arms) for CRP were included. The pooled analysis showed that the administration of phytosterol did not significantly reduce CRP compared to control with WMD= -0.04 mg/l (95% CI: -0.28 to 0.20, P = 0.74). However, phytosterol supplementation significantly decreased the hs-CRP level compared to the control group with WMD of -0.25 mg/l (95% CI: -0.42 to -0.07, P = 0.006). The WMD for hs-CRP reduction was - 0.36 mg/l (95% CI: -0.53 to -0.18, P < 0.001) for supplementation with a phytosterol dose ≥ 2000 mg/day compared to the control group.

conclusionsPhytosterol supplementation may be effective in reducing hs-CRP levels.

Indexed as

BiomarkersC-Reactive ProteinDietary SupplementsPhytosterolsAdultAgedAnti-Inflammatory AgentsDown-RegulationFemaleHumansInflammation MediatorsMaleMiddle AgedRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeAnti-Inflammatory AgentsBiomarkersC-Reactive ProteinInflammation MediatorsPhytosterolsCardiovascular diseaseCRPHs-CRPPhytosterol

Identifiers

PMID39476284

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.