ArticleCancer discovery2025
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Abstract read
In one paragraph
Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Cuproptosis and the bioinorganic basis of copper-induced cell death.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Review
- Copper, cuproptosis, and cancer: biology concepts of a novel cell death.Apoptosis : an international journal on programmed cell death · 2026Review
- Copper Metabolism-Related Cell Death in Kidney Diseases: Molecular Mechanisms, Disease-Specific Evidence, and Translational Implications.International journal of molecular sciences · 2026Review
- Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity.Nature cancer · 2026Article
- Copper homeostasis and cuproptosis rewire the tumor microenvironment: mechanisms, immune modulation, and therapeutic opportunities.Journal of hematology & oncology · 2026Review
- Trimodal, uncertainty-guided whole-slide framework for genome-scale spatial expression and image-only virtual perturbation in cancer cohorts.Genome medicine · 2026Article
- Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS).The Journal of biological chemistry · 2026Article
- The cross-talk and interplay between ferroptosis and cuproptosis in tumor and therapeutics.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Suppression of ASNS expression by VHL-mediated ubiquitination hinders the progression of renal cell carcinoma through enhancing JUP expression and inhibiting PI3K-AKT and MAPK pathways.International journal of biological sciences · 2026Article
- Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review).International journal of molecular medicine · 2026Review
- Unraveling the role of LINC02657 in clear cell renal cell carcinoma: insights into tumor aggression, immune modulation, and treatment response.Frontiers in immunology · 2026Article
- Decoding cuproptosis and cuproplasia: implications for therapeutic strategies in renal cell carcinoma.Cell death discovery · 2025Review
- Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1.Journal of the American Chemical Society · 2025Article
- [Metabolic reprogramming by glutathione S-transferase enhances environmental adaptation ofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- Single-cell sequencing technology in renal cancer: insights into tumor biology and clinical application.Biomarker research · 2025Review
- Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data.Molecular & cellular proteomics : MCP · 2025Article
- Blood and Serum Copper and Zinc Levels and 10-Year Survival of Patients After Kidney Cancer Diagnosis.Nutrients · 2025Article
- STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells.Cell division · 2024Article
Corrections and comments
- Update of
Authors and funding
26 authors.
Megan E Bischoff *Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-7950-2825
Behrouz Shamsaei *Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-0672-5382
Juechen Yang *Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-7956-8592
Dina Secic *Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-0041-1294
Bhargav VemuriDepartment of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-7031-8116
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0002-7296-4963
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0002-2258-6490
Caterina BartolacciDivision of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0003-2002-7721
Rafal AdamczakInstitute of Engineering and Technology, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Torun, Poland.ORCID 0000-0002-0261-8184
Lucas SchmidtTrace Elements Group, Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-4496-0487
Jiang WangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-6899-1678
Amelia MartinesDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0009-0005-0059-9230
Jahnavi VenkatDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0009-0004-5735-5504
Vanina Toffessi TcheuyapKidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-6817-9241
Jacek BiesiadaDivision of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0003-0435-2225
Catherine A BehrmannDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0003-0704-0884
Katherine E VestDepartment of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-3391-8649
James BrugarolasKidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-8575-499X
Pier Paolo ScaglioniDivision of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-6036-5138
David R PlasDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0001-7568-1400
Krushna C PatraDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-2386-6435
Shuchi GulatiDivision of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0001-6793-9694
Julio A Landero FigueroaTrace Elements Group, Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-8641-0497
Jarek MellerDepartment of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-1162-8253
John T CunninghamDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0001-6490-4533
Maria F Czyzyk-KrzeskaDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-0693-8214
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MUniversity of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Payal Kapur, Payal Kapur · 2016 to 2026
$24.7MENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9MFunction and regulation of copper in mammalian tissue differentiationR35GM146878 · NIGMS · UNIVERSITY OF CINCINNATI · PI Katherine Elizabeth Vest · 2022 to 2026
$2.4MMetabolic effects of cooper in renal cancerR01CA287260 · NCI · UNIVERSITY OF CINCINNATI · PI Maria F Czyzyk-Krzeska · 2023 to 2026
$2.2MDefining the biological roles of PRPS isozymes in normal and diseased settingsR35GM133561 · NIGMS · UNIVERSITY OF CINCINNATI · PI CUNNINGHAM, TOM · 2019 to 2023
$2.1MPost-Graduate Hematology/Oncology Translational (PG-HOT) Training ProgramT32CA236764 · NCI · UNIVERSITY OF CINCINNATI · PI QI, XIAOYANG, SCAGLIONI, PIER PAOLO · 2019 to 2023
$2.1MCo-targeting S6 and TAM kinases in PTEN-deficient glioblastomaR01CA239657 · NCI · UNIVERSITY OF CINCINNATI · PI PLAS, DAVID R · 2020 to 2024
$2.1MFatty acid metabolism regulates ferroptosis in mutant KRAS lung cancerR01CA259845 · NCI · UNIVERSITY OF CINCINNATI · PI PIER Paolo SCAGLIONI · 2022 to 2026
$2.0MInvestigating Mechanisms of Deregulated Nucleotide Metabolism in CancerR01CA230904 · NCI · UNIVERSITY OF CINCINNATI · PI CUNNINGHAM, TOM · 2019 to 2023
$1.8MInvestigating the molecular mechanisms of growth in GNAS mutant pancreatic cancer.R37CA272854 · NCI · UNIVERSITY OF CINCINNATI · PI Krushna Chandra Patra · 2022 to 2026
$1.8MMechanisms of selective autophagyR01GM128216 · NIGMS · UNIVERSITY OF CINCINNATI · PI CZYZYK-KRZESKA, MARIA F · 2019 to 2022
$1.4MBLRD VA I01 BX001110National Cancer Institute (NCI) K08CA273542National Cancer Institute (NCI) P30CA046934National Cancer Institute (NCI) P50CA196516National Cancer Institute (NCI) R01CA230904National Cancer Institute (NCI) R01CA239657National Cancer Institute (NCI) R01CA259845National Cancer Institute (NCI) R01CA287260National Cancer Institute (NCI) R37CA272854National Cancer Institute (NCI) T32CA17846National Cancer Institute (NCI) T32CA236764National Institute of General Medical Sciences (NIGMS) R01GM128216National Institute of General Medical Sciences (NIGMS) R35GM133561National Institute of General Medical Sciences (NIGMS) R35GM146878NCI NIH HHS K08 CA273542NCI NIH HHS P30 CA046934NCI NIH HHS P50 CA196516NCI NIH HHS R01 CA230904NCI NIH HHS R01 CA239657NCI NIH HHS R01 CA259845NCI NIH HHS R01 CA287260NCI NIH HHS R37 CA272854NCI NIH HHS T32 CA236764NIEHS NIH HHS T32 ES007250NIGMS NIH HHS R01 GM128216NIGMS NIH HHS R35 GM133561NIGMS NIH HHS R35 GM146878NIH ESI T32ES007250Veteran Administration 2I01BX001110
Abstract
significanceThe work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.
Indexed as
Carcinoma, Renal CellCopperKidney NeoplasmsAnimalsDisease ProgressionHumansMiceCopper
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.