Evidence map›Paper›PMID 39476434›Full record

ArticleNeurobiology of aging2025

Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice.

Grace C Smith, Keith R Griffith, Avery R Sicher, Dakota F Brockway, Elizabeth A Proctor, Nicole A Crowley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Ethanol Alters the Neurexin Landscape in Human Neuroblastoma Cells.Alcohol, clinical & experimental research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Grace C SmithDepartment of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA.
Keith R GriffithDepartment of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA.
Avery R SicherDepartment of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Neuroscience Graduate Program, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA.
Dakota F BrockwayDepartment of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Neuroscience Graduate Program, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA.
Elizabeth A ProctorDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Department of Engineering Science and Mechanics, University Park, PA 16802, USA; Departments of Neurosurgery Penn State College of Medicine, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA; Departments of Neurosurgery Penn State College of Medicine, Hershey, PA 17033, USA.
Nicole A CrowleyDepartment of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Departments of Neurosurgery Penn State College of Medicine, University Park, PA 16802, USA; Penn State Neuroscience Institute, University Park, PA 16802, USA. Electronic address: nzc27@psu.edu.

Funding

Impaired Vasoreactivity, Sleep Degradation, and Impaired Clearance in the APOE4 BrainR01AG072513 · NIA · UNIVERSITY OF VIRGINIA · PI Patrick James Drew, Bruce J Gluckman · 2022 to 2026
$3.8M
Prelimbic somatostatin peptide signaling in binge ethanol consumptionR01AA029403 · NIAAA · PENNSYLVANIA STATE UNIVERSITY, THE · PI Nicole Ashley Crowley · 2022 to 2026
$1.9M
Investigating the effects of adolescent binge drinking on prelimbic somatostatin circuitryF31AA030455 · NIAAA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SICHER, AVERY · 2022 to 2024
$111k
NIAAA NIH HHS F31 AA030455NIAAA NIH HHS R01 AA029403NIA NIH HHS R01 AG072513
6 · The paper itself

Abstract

Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of alcohol use on excitation and inhibition on the aging brain is unclear. We examined the effect of moderate voluntary binge alcohol consumption on the aged, pre-disease neuronal environment by measuring intrinsic excitability and spontaneous neurotransmission on prefrontal cortical pyramidal (excitatory, glutamatergic) and non-pyramidal (inhibitory, GABAergic) neurons following a prolonged period of abstinence from alcohol in mice. Results highlight that binge alcohol consumption has lasting impacts on the electrophysiological properties of prefrontal cortical neurons. A profound increase in excitatory events onto layer 2/3 non-pyramidal neurons following alcohol consumption was seen, along with altered intrinsic excitability of pyramidal neurons, which could have a range of effects on cognitive disorder progression, such as Alzheimer's Disease, in humans. These results indicate that moderate voluntary alcohol influences the pre-disease environment in aging and highlight the need for further mechanistic investigation into this risk factor.

Indexed as

AgingMice, Inbred C57BLPrefrontal CortexSynaptic TransmissionAlcohol DrinkingAnimalsBinge DrinkingCognitive DysfunctionMaleMiceNeuronsNeurotransmitter AgentsPyramidal CellsSignal TransductionNeurotransmitter AgentsalcoholAlzheimer’s Diseasebinge drinkingelectrophysiologyprefrontal cortex

Identifiers

PMID39476434
PMCPMC11725176

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.