Evidence map›Paper›PMID 39477410›Full record

ArticleIn vivo (Athens, Greece)

Potential Medicinal Efficacy of Alkaline Extract of Pine Seed Shell: Anti-UVC Activity and Macrophage Activation.

Alejandro Mena Acra, Shin Uota, Masaaki Yoshihara, Yukio Murakami, Hiroshi Sakagami

Abstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Quantification ofIn vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alejandro Mena Acra *Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
Shin Uota *Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
Masaaki YoshiharaNippon Sunshow Medicine Manufacture Co. Ltd., Nagoya, Japan.
Yukio MurakamiDivision of Oral Diagnosis and General Dentistry, Meikai University School of Dentistry, Sakado, Japan.
Hiroshi SakagamiMeikai University Research Institute of Odontology (M-RIO), Saitama, Japan; sakagami@dent.meikai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAlkaline extracts of several plants which contain lignin degradation products have several unique biological activities. In order to search for new biological activities of alkaline extracts of pine seed shell (APs), their anti-ultraviolet C (UVC) and macrophage stimulation activity were investigated. MATERIALS AND

methodsAnti-UVC activity was determined by the ratio of the 50% cytotoxic concentration against human melanoma cell line COLO679 to the 50% UVC-protective concentration. Extracellularly secreted nitrite (NO

resultsAPs showed significantly higher anti-UVC activity than previously reported hot-water extracts of medical herbs. Anti-UVC activity of AP and vanillic acid was maintained for much longer than that of sodium ascorbate and vanillin. APs enhanced the production of NO

conclusionThe present study suggests the possible application of APs as UVC protectors and immunopotentiators via macrophage activation.

Indexed as

Macrophage ActivationMacrophagesPinusPlant ExtractsSeedsUltraviolet RaysAnimalsCell Line, TumorCell SurvivalHumansLipopolysaccharidesMiceNitritesRAW 264.7 CellsVanillic AcidLipopolysaccharidesNitritesPlant ExtractsVanillic Acidalkaline extractmacrophage activationpine seed shellUVC protection

Identifiers

PMID39477410
PMCPMC11535912

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.