Evidence map›Paper›PMID 39477498›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

FAP and PSMA Expression by Immunohistochemistry and PET Imaging in Castration-Resistant Prostate Cancer: A Translational Pilot Study.

Rong Rong Huang, Chunlai Zuo, Christine E Mona, Adrien Holzgreve, Colm Morrissey, Peter S Nelson, Lauren Brady, Lawrence True, Anthony Sisk, Johannes Czernin and 2 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Comparison of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Article
  4. FAP Expression in Renal Tumors Assessed by [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Article
  6. Performance of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Multitracer comparison of gold standard PSMA-PET/CT withEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Dual targeting PET tracer [Theranostics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rong Rong HuangDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California.
Chunlai ZuoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California.
Christine E MonaAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Adrien HolzgreveAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Colm MorrisseyDepartment of Urology, University of Washington, Seattle, Washington.
Peter S NelsonDivisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington.
Lauren BradyDivisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington.
Lawrence TrueDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington; and.
Anthony SiskDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California.
Johannes CzerninAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Jeremie CalaisAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California; huihui.ye@cshs.org jcalais@mednet.ucla.edu.
Huihui YeDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California; huihui.ye@cshs.org jcalais@mednet.ucla.edu.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Defining and Targeting Lineage Transition Programs Operative in AR Pathway Independent Prostate CancerR01CA234715 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NELSON, PETER S · 2020 to 2024
$2.0M
Targeting Vulnerabilities Exposed by Cancer Treatment-Induced Lineage PlasticityR01CA266452 · NCI · FRED HUTCHINSON CANCER CENTER · PI PETER S NELSON · 2022 to 2026
$2.0M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA097186NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA234715NCI NIH HHS R01 CA266452
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA) is a theranostic target for metastatic prostate cancer (PCa). However, castration-resistant PCa (CRPC) may lose PSMA expression after systemic therapy. Fibroblast activation protein (FAP), expressed by carcinoma-associated fibroblasts in various cancer types, including PCa, has the potential to be an alternative target. In this study, we evaluated FAP expression in CRPC to assess its potential, using PSMA as a comparison.

Indexed as

Antigens, SurfaceEndopeptidasesGlutamate Carboxypeptidase IIImmunohistochemistryProstatic Neoplasms, Castration-ResistantSerine EndopeptidasesAgedAged, 80 and overClinical Trials, Phase I as TopicFibroblast Activation Protein AlphaGelatinasesGene Expression Regulation, NeoplasticHumansMaleMembrane ProteinsMiddle AgedAntigens, SurfaceEndopeptidasesFibroblast Activation Protein AlphaFOLH1 protein, humanGelatinasesGlutamate Carboxypeptidase IIMembrane ProteinsSerine EndopeptidasesCRPCFAPifibroblast activation proteinPET/CTprostate cancerPSMA

Identifiers

PMID39477498
PMCPMC11619584

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.