Evidence map›Paper›PMID 39477865›Full record

ArticleGeroScience2025

Neurocognitive correlates of cerebral mitochondrial function and energy metabolism using phosphorus magnetic resonance spectroscopy in older adults.

Francesca V Lopez, Andrew O'Shea, Zhiguang Huo, Steven T DeKosky, Theodore P Trouard, Gene E Alexander, Adam J Woods, Dawn Bowers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca V LopezDepartment of Clinical and Health Psychology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA. frl001@health.ucsd.edu.ORCID 0000-0003-0875-7326
Andrew O'SheaCenter for Cognitive Aging and Memory, Evelyn F. McKnight Brain Institute, University of Florida, Gainesville, Gainesville, FL, USA.
Zhiguang HuoDepartment of Biostatistics, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.
Steven T DeKoskyDepartment of Neurology and Fixel Center for Neurological Diseases, College of Medicine, University of Florida and Evelyn F. McKnight Brain Institute, Gainesville, FL, USA.
Theodore P TrouardDepartment of Biomedical Engineering, College of Engineering, and Evelyn F. McKnight Brain Institute, University of Arizona and Alzheimer's Disease Consortium, Tucson, AZ, USA.
Gene E AlexanderDepartment of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
Adam J WoodsDepartment of Clinical and Health Psychology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.
Dawn BowersDepartment of Clinical and Health Psychology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.

Funding

Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI Nicholas Ashton · 2021 to 2026
$24.9M
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation: Diversity SupplementR01AG064587 · NIA · UNIVERSITY OF FLORIDA · PI ALEXANDER, GENE E, BOWERS, DAWN · 2019 to 2023
$4.0M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Cognitive Correlates of Mitochondrial Function in Older AdultsF31AG071264 · NIA · UNIVERSITY OF FLORIDA · PI LOPEZ, FRANCESCA VEANNA · 2021 to 2022
$61k
NIA NIH HHS F31AG071264NIA NIH HHS P30 AG072980NIA NIH HHS P30AG072980NIA NIH HHS R01AG64587NINDS NIH HHS T32 NS082168NINDS NIH HHS T32NS082168
6 · The paper itself

Abstract

The goal of the current study was to learn about the role of cerebral mitochondrial function on cognition. Based on established cognitive neuroscience, clinical neuropsychology, and cognitive aging literature, we hypothesized mitochondrial function within a focal brain region would map onto cognitive behaviors linked to that brain region. To test this hypothesis, we used phosphorous (

Indexed as

BrainCognitionEnergy MetabolismMitochondriaAgedAged, 80 and overExecutive FunctionFemaleHumansMagnetic Resonance SpectroscopyMaleNeuropsychological TestsPhosphorusPhosphorusExecutive functionMitochondriaOlder adultsPhosphate brain energy metabolismPhosphorus magnetic resonance spectroscopyRecent memory

Identifiers

PMID39477865
PMCPMC11978590

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.