Evidence map›Paper›PMID 39478095›Full record

ArticleScientific reports2024

Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model.

Timothy D Allerton, James E Stampley, Zhen Li, Xiaoman Yu, Heather Quiariate, Jake E Doiron, Ginger White, Zach Wigger, Manas Ranjan Gartia, David J Lefer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Timothy D AllertonVascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA. timothy.allerton@pbrc.edu.
James E StampleyDepartment of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
Zhen LiDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Xiaoman YuDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Heather QuiariateVascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Jake E DoironVascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Ginger WhiteDepartment of Psychology, Louisiana State University, Baton Rouge, LA, USA.
Zach WiggerAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Manas Ranjan GartiaDepartment of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA, USA.
David J LeferDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Paul SotoDepartment of Psychology, Louisiana State University, Baton Rouge, LA, USA.
Brian A IrvingDepartment of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Christopher D Morrison · 2020 to 2026
$18.4M
Mentoring Obesity and Diabetes Research in LouisianaP20GM103528 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2012 to 2015
$8.8M
Spatial metabolomics with subcellular resolution to identify therapeutic targetsR35GM150564 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Manas Ranjan Gartia · 2023 to 2026
$1.5M
NIDDK NIH HHS P30 DK072476NIGMS NIH HHS P20 GM103528NIGMS NIH HHS P20 GM135002NIGMS NIH HHS R35 GM150564
6 · The paper itself

Abstract

Reduced nitric oxide (NO) bioavailability is a pathological link between obesity and Alzheimer's disease (AD). Obesity-associated metabolic and mitochondrial bioenergetic dysfunction are key drivers of AD pathology. The hypothalamus is a critical brain region during the development of obesity and dysfunction is an area implicated in the development of AD. NO is an essential mediator of blood flow and mitochondrial bioenergetic function, but the role of NO in obesity-AD is not entirely clear. We investigated diet-induced obesity in female APPswe/PS1dE9 (APP) mouse model of AD, which we treated with two different NO donors (sodium nitrite or L-citrulline). After 26 weeks of a high-fat diet, female APP mice had higher adiposity, insulin resistance, and mitochondrial dysfunction (hypothalamus) than non-transgenic littermate (wild type) controls. Treatment with either sodium nitrite or L-citrulline did not reduce adiposity but improved whole-body energy expenditure, substrate oxidation, and insulin sensitivity. Notably, both NO donors restored hypothalamic mitochondrial respiration in APP mice. Our findings suggest that NO is an essential mediator of whole-body metabolism and hypothalamic mitochondrial function, which are severely impacted by the dual insults of obesity and AD pathology.

Indexed as

Alzheimer DiseaseDiet, High-FatDisease Models, AnimalMice, TransgenicMitochondriaNitric Oxide DonorsObesityAnimalsCitrullineEnergy MetabolismFemaleHumansHypothalamusInsulin ResistanceMiceNitric OxideCitrullineNitric OxideNitric Oxide DonorsSodium Nitrite

Identifiers

PMID39478095
PMCPMC11525932

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.