Evidence map›Paper›PMID 39478215›Full record

ArticleNature2024

Myocardial infarction augments sleep to limit cardiac inflammation and damage.

Pacific Huynh, Jan D Hoffmann, Teresa Gerhardt, Máté G Kiss, Faris M Zuraikat, Oren Cohen, Christopher Wolfram, Abi G Yates, Alexander Leunig, Merlin Heiser and 27 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Review
  2. Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. [Lactate induces gastric mucosal injury by promoting M1 polarization of macrophagesNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Metabolism-Mediated Regulation of Brain-Heart Interactions.International journal of molecular sciences · 2026
    Review
  16. Review
  17. PET imaging of cardiac sympathetic nervous system dysfunction using meta-[European journal of nuclear medicine and molecular imaging · 2026
    Article
  18. Review
  19. Article
  20. Cross-Organ Neuroimmunology of Behavior.Annual review of immunology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

Pacific Huynh *Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jan D Hoffmann *Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Teresa GerhardtCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Máté G KissCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Faris M ZuraikatCenter of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Oren CohenCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0004-2827-9063
Christopher WolframDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany.ORCID 0009-0002-8113-9102
Abi G YatesCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander LeunigCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9179-9203
Merlin HeiserCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5232-0688
Lena GaebelCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matteo GianeselliCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3726-3595
Sukanya GoswamiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Annie KhamhoungCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeffrey DowneyCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seonghun YoonCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhihong ChenHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7403-7015
Vladimir RoudkoHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Travis DawsonHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joana Ferreira da SilvaCenter for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Natalie J AmeralDepartment of Pathology, Harvard Medical School, Boston, MA, USA.
Jarod Morgenroth-RebinCenter for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Darwin D'SouzaHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura L KoekkoekCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Walter JacobCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9649-4989
Jazz MunitzCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9173-2666
Donghoon LeeFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0453-6059
John F FullardFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9874-2907
Mandy M T van LeentCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9747-1022
Panos RoussosFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4640-6239
Seunghee Kim-SchulzeHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neomi ShahDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benjamin P KleinstiverCenter for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5469-0655
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3163-9152
David LeistnerDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany.
Marie-Pierre St-OngeCenter of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-1354-1749
Cameron S McAlpineCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.ORCID 0000-0002-9832-6345

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
PROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
The adaptive-innate immune interactome across multiple tissues in Alzheimer's diseaseR01AG082185 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VAHRAM HAROUTUNIAN, Donghoon Lee · 2023 to 2026
$9.0M
TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6M
Mechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic healthR35HL155670 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARIE-PIERRE ST-ONGE · 2021 to 2026
$5.4M
Translational Immunology Training ProgramT32AI078892 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum, SERGIO A. LIRA · 2008 to 2026
$4.5M
Imaging the Atherosclerosis Cascade in Sleep ApneaR01HL143221 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHAH, NEOMI A · 2018 to 2022
$4.2M
Effect of long-term sleep restriction on energy balanceR01HL128226 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ST-ONGE, MARIE-PIERRE · 2016 to 2019
$3.4M
Scalable Development of Custom Genome Editing TechnologiesDP2CA281401 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KLEINSTIVER, BENJAMIN PETER · 2022 to 2025
$2.5M
Application of Machine Learning to Identify Obstructive Sleep Apnea Subgroups at Risk for Atherosclerosis Progression and Cardiovascular Disease Events (OSA-GRANDE)R01HL168897 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Girish Nitin Nadkarni, Mayte Suarez-Farinas · 2024 to 2026
$2.3M
Influence of sleep on the hematopoietic niche and atherosclerosis during agingR01HL158534 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2025
$2.1M
NCATS NIH HHS UL1 TR001873NCI NIH HHS DP2 CA281401NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R00 HL151750NHLBI NIH HHS R01 HL128226NHLBI NIH HHS R01 HL143221NHLBI NIH HHS R01 HL158534NHLBI NIH HHS R01 HL168897NHLBI NIH HHS R35 HL155670NHLBI NIH HHS T32 HL007343NHLBI NIH HHS T32 HL007824NHLBI NIH HHS T32 HL160511NIAID NIH HHS T32 AI078892NIA NIH HHS R01 AG082185
6 · The paper itself

Abstract

Sleep is integral to cardiovascular health

Indexed as

InflammationMyocardial InfarctionMyocardiumSleepAnimalsChemotaxis, LeukocyteChoroid PlexusFemaleGlutamic AcidHeartHeart RateHumansLateral Thalamic NucleiMacrophagesMaleMiceGlutamic AcidReceptors, Adrenergic, beta-2Receptors, Tumor Necrosis Factor, Type ITNFRSF1A protein, humanTnfrsf1a protein, mouseTumor Necrosis Factors

Identifiers

PMID39478215
PMCPMC11998484

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.