Evidence map›Paper›PMID 39478231›Full record

ArticleNature2024

Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei.

Alexander K Beaver, Zhibek Keneskhanova, Raúl O Cosentino, Brian L Weiss, Erick O Awuoche, Gretchen M Smallenberger, Gracyn Y Buenconsejo, Nathan P Crilly, Jaclyn E Smith, Jill M C Hakim and 7 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Why Euglenozoans.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Alexander K BeaverDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0009-0000-6314-5934
Zhibek KeneskhanovaDivision of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Raúl O CosentinoDivision of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0003-2124-8198
Brian L WeissDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Erick O AwuocheDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Gretchen M SmallenbergerDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Gracyn Y BuenconsejoDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Nathan P CrillyDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jaclyn E SmithDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-2392-0585
Jill M C HakimDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Bailin ZhangDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-7606-4014
Bryce BobbDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Filipa Rijo-FerreiraDivision of Infectious Diseases and Vaccinology, Berkeley Public Health Molecular and Cell Biology Department, Berkeley, CA, USA.ORCID 0000-0002-4003-020X
Luisa M FigueiredoGulbenkian Institute for Molecular Medicine, Lisboa, Portugal.ORCID 0000-0002-5752-6586
Serap AksoyDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0001-9941-143X
T Nicolai SiegelDivision of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-1715-7907
Monica R MugnierDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. mmugnie1@jhu.edu.ORCID 0000-0002-1535-2530

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Molecular Aspects of Tsetse and Trypanosome TransmissionR01AI051584 · NIAID · YALE UNIVERSITY · PI AKSOY, SERAP · 2003 to 2013
$4.3M
Trypanosome Transmission Biology in TsetseR01AI158805 · NIAID · YALE UNIVERSITY · PI Serap AKSOY · 2022 to 2026
$4.1M
Variant surface glycoprotein diversification in Trypanosoma bruceiDP5OD023065 · OD · JOHNS HOPKINS UNIVERSITY · PI MUGNIER, MONICA · 2016 to 2020
$2.1M
MoFlo to MoFlo XDP Upgrade for BSL3 SortingS10OD016315 · OD · JOHNS HOPKINS UNIVERSITY · PI MARGOLICK, JOSEPH B. · 2013 to 2013
$233k
Elucidating the mechanism for malaria rhythmicity: an underlying circadian clock of the parasiteK99GM132557 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RIJO-FERREIRA, FILIPA · 2019 to 2021
$122k
NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI051584NIAID NIH HHS R01 AI158805NIAID NIH HHS T32 AI007417NIGMS NIH HHS K99 GM132557NIH HHS DP5 OD023065NIH HHS S10 OD016315NIH HHS T32 OD011089
6 · The paper itself

Abstract

The protozoan parasite Trypanosoma brucei evades clearance by the host immune system through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically 'switching' expression of the VSG using a large genomic repertoire of VSG-encoding genes

Indexed as

Antigenic VariationAntigens, ProtozoanTrypanosoma brucei bruceiTrypanosomiasis, AfricanVariant Surface Glycoproteins, TrypanosomaAnimalsFemaleHigh-Throughput Nucleotide SequencingMiceMice, Inbred C57BLMice, KnockoutRNA-SeqTsetse FliesAntigens, ProtozoanVariant Surface Glycoproteins, Trypanosoma

Identifiers

PMID39478231
PMCPMC11634766

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.