Evidence map›Paper›PMID 39478527›Full record

ArticleBMC veterinary research2024

The clinical efficacy of cGMP-specific sildenafil on mitochondrial biogenesis induction and renal damage in cats with acute on chronic kidney disease.

Mehmet Maden, Merve Ider, Mehmet Erman Or, Banu Dokuzeylül, Erdem Gülersoy, Merve Cansu Kılıçkaya, Bengü Bilgiç, Murat Kaan Durgut, Semih İzmirli, Suleyman Serhat Iyigün and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mehmet MadenFaculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye. mmaden@selcuk.edu.tr.ORCID http://orcid.org/0000-0003-2954-6763
Merve IderFaculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye.ORCID http://orcid.org/0000-0003-2928-5452
Mehmet Erman OrFaculty of Veterinary Medicine, Internal Medicine Department, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-8764-1956
Banu DokuzeylülFaculty of Veterinary Medicine, Internal Medicine Department, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-3086-4726
Erdem GülersoyFaculty of Veterinary Medicine, Department of Internal Medicine, Harran University, Şanlıurfa, Türkiye.ORCID http://orcid.org/0000-0001-8511-0150
Merve Cansu KılıçkayaFaculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye.ORCID http://orcid.org/0000-0002-7130-6555
Bengü BilgiçFaculty of Veterinary Medicine, Internal Medicine Department, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-6952-2937
Murat Kaan DurgutFaculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye.ORCID http://orcid.org/0000-0002-4582-8536
Semih İzmirliFaculty of Veterinary Medicine, Internal Medicine Department, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-1781-0494
Suleyman Serhat IyigünFaculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye.ORCID http://orcid.org/0000-0002-3270-1931
Deniz Zeynep TelciFaculty of Veterinary Medicine, Internal Medicine Department, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0001-6825-2093
Amir NaseriFaculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye.ORCID http://orcid.org/0000-0001-9140-5879

Funding

The Scientific and Technological Research Council of Türkiye (TUBİTAK) 120O988The Scientific Research Projects Coordinatorship of Selcuk University (SUBAP) 22401056
6 · The paper itself

Abstract

backgroundMitochondrial biogenesis (MB) induction has recently emerged as potential therapeutic approaches in kidney pathology and the mitochondria-targeted therapies should be investigated to improve treatment of animals with kidney diseases. This study aimed to investigate the effects of MB induction with sildenafil citrate on the cGMP/NO pathway, glomerular filtration, and reduction of kidney damage and fibrosis (TGF-β/SMAD pathway) in cats with acute on chronic kidney disease (ACKD). Thirty-three cats were divided into the non-azotemic (healthy) group (n:8) and the ACKD group (n:25), comprising different breeds, sexes, and ages. Sildenafil citrate was administered to the non-azotemic and ACKD groups (2.5 mg/kg, PO, q12 hours) for 30 days. Serum and urine NO, MDA, NGAL, KIM-1, TGF-β1, IL-18, FGF 23, PGC-1α and cGMP concentrations were measured.

resultsSerum cGMP concentrations increased (P < 0.05) in the non-azotemic group during the 2

conclusionsWhile sildenafil citrate has been determined to induce a low level of MB and to have a beneficial effect on glomerular filtration, it is observed to be ineffective in mitigating renal damage and fibrosis via the TGF-β/SMAD pathway in cats with ACKD.

Indexed as

Cat DiseasesCyclic GMPRenal Insufficiency, ChronicSildenafil CitrateAnimalsCatsFemaleGlomerular Filtration RateKidneyMaleMitochondriaNitric OxideOrganelle BiogenesisCyclic GMPNitric OxideSildenafil CitrateAzotemiaCatMitochondrial biogenesisSildenafil citrateUrinary biomarker

Identifiers

PMID39478527
PMCPMC11526613

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.