Evidence map›Paper›PMID 39480093›Full record

ArticleApplied and environmental microbiology2024

Corynebacterial membrane vesicles disrupt cariogenic interkingdom assemblages.

Puthayalai Treerat, Tanner Rozendal, Camilla de Mattos, Anli Davis, Emily Helliwell, Justin Merritt, Jens Kreth

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Aspirin Combined with Antifungal Drugs SuppressesJournal of microbiology and biotechnology · 2025
    Article
  6. Microbiome variability and role ofJournal of oral microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Puthayalai TreeratBiomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University (OHSU), Portland, Oregon, USA.
Tanner RozendalClark Honors College, University of Oregon, Eugene, Oregon, USA.
Camilla de MattosBiomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University (OHSU), Portland, Oregon, USA.
Anli DavisLewis & Clark College, Portland, Oregon, USA.
Emily HelliwellBiomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University (OHSU), Portland, Oregon, USA.
Justin MerrittBiomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University (OHSU), Portland, Oregon, USA.ORCID 0000-0002-3464-0490
Jens KrethBiomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University (OHSU), Portland, Oregon, USA.ORCID 0000-0002-8599-8310

Funding

Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiomeR01DE029492 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2024
$2.5M
PORT (Portland Oral health Research Training)T90DE030859 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI WU, HUI · 2021 to 2025
$2.1M
Opening Dental and Oral Research Summers (DORS) to Scientific Careers throughout OregonR25DE032536 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KIRSTEN Jeanne LAMPI, Hui Wu · 2023 to 2026
$510k
Streptococcal secretion of pyruvate - a novel antioxidant strategy in the oral biofilmR21DE029612 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2021
$424k
HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE028252HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE029612,DE029492NIDCR NIH HHS R01 DE029492NIDCR NIH HHS R21 DE029612NIDCR NIH HHS R25 DE032536NIDCR NIH HHS R35 DE028252NIDCR NIH HHS T90 DE030859
6 · The paper itself

Abstract

Polymicrobial diseases such as periodontal disease and caries pose significant treatment challenges due to their resistance to common approaches like antibiotic therapy. These infections exhibit increased resilience, due to microbial interactions that also disrupt host immune responses. Current research focuses on virulence and disease-promoting interactions, but less is known about interactions that could inhibit or prevent disease development. Normally human-associated microbiomes maintain homeostasis, preventing pathobionts from becoming dominant. In conditions like chronic disseminated candidiasis or severe early childhood caries (s-ECC), an overgrowth of microbes such as

Indexed as

Candida albicansCorynebacteriumDental CariesStreptococcus mutansAnimalsBiofilmsExtracellular VesiclesHumansMicrobial InteractionsVirulenceCandida albicanscariescommensalspolymicrobialStreptococcus mutans

Identifiers

PMID39480093
PMCPMC11577751

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.