SynthesisJournal of psychopathology and clinical science2024
The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.
Synthesis in Journal of psychopathology and clinical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tree Imagery in Drawing Tests for Screening Mental Disorders: A Systematic Review and Meta-Analysis.Depression and anxiety · 2026Pooled it
- Global research landscape, knowledge structure, and emerging trends in adverse childhood experiences and personality disorders: a bibliometric analysis.Frontiers in psychiatry · 2026Pooled it
- Using the Hierarchical Taxonomy of Psychopathology (HiTOP) for precision psychiatry.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Developmental predictors of suicide attempts from childhood to early adulthood: a 15-year prospective cohort study.Lancet regional health. Americas · 2026Article
- Shared and distinct features between interpersonal and self-directed violent behaviors: a simulated intervention network study.BMC public health · 2026Article
- Distinct Event-Related-Potential Biomarkers of Broad Versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- Psychological and somatic distress profiles in young adults in and out of conflict settings: a cluster-based analysis of three population-based studies in Ukraine and Switzerland.Frontiers in public health · 2026Article
- Task-aligned outcome learning in psychiatry: reducing endpoint dilution.Frontiers in psychiatry · 2026Article
- Executive Functioning Profiles in Children with Neurodevelopmental Disorders.Behavioral sciences (Basel, Switzerland) · 2025Article
- Recent advances in the conceptualization and evidence supporting the HiTOP approach.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology.Psychological medicine · 2025Article
- The future of diagnosis in mental health: Promises and challenges of biomarkers to identify reliable and highly predictive biosignatures of affective disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Review
- Embracing variability in the search for biological mechanisms of psychiatric illness.Trends in cognitive sciences · 2025Review
- Dimensional latent structure of internet gaming disorder symptoms in four representative surveys of German adolescents: results from taxometric analyses.Frontiers in psychiatry · 2025Article
- Psychiatry in the real world.Frontiers in psychiatry · 2025Article
- Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology.Psychological medicine · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Understanding the neurobiological mechanisms involved in psychopathology has been hindered by the limitations of categorical nosologies. The Hierarchical Taxonomy of Psychopathology (HiTOP) is an alternative dimensional system for characterizing psychopathology, derived from quantitative studies of covariation among diagnoses and symptoms. HiTOP provides more promising targets for clinical neuroscience than traditional psychiatric diagnoses and can facilitate cumulative integration of existing research. We systematically reviewed 164 human neuroimaging studies with sample sizes of 194 or greater that have investigated dimensions of psychopathology classified within HiTOP. Replicated results were identified for constructs at five different levels of the hierarchy, including the overarching p-factor, the externalizing superspectrum, the thought disorder and internalizing spectra, the distress subfactor, and the depression symptom dimension. Our review highlights the potential of dimensional clinical neuroscience research and the usefulness of HiTOP while also suggesting limitations of existing work in this relatively young field. We discuss how HiTOP can be integrated synergistically with neuroscience-oriented, transdiagnostic frameworks developed by the National Institutes of Health, including the Research Domain Criteria, Addictions Neuroclinical Assessment, and the National Institute on Drug Abuse's Phenotyping Assessment Battery, and how researchers can use HiTOP to accelerate clinical neuroscience research in humans and other species. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.