Evidence map›Paper›PMID 39480623›Full record

ArticleBiological trace element research2025

Effect of Voluntary Wheel Running on Anxiety- and Depression-Like Behaviors in Fluoride-Exposed Mice.

Mengjie Qi, Yue Wu, Han Shi, Jie Liu, Run Zhu, Jixiang Wang, Amna Rafique, Bo Yang, Ruiyan Niu, Ding Zhang and 1 more

Abstract read
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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengjie QiCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Yue WuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Han ShiCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Jie LiuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Run ZhuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Jixiang WangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Amna RafiqueCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Bo YangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Ruiyan NiuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China.
Ding ZhangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China. zdlucky2014@sina.com.
Zilong SunCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, PR China. sunzilong2000@outlook.com.

Funding

This research was supported by the special fund for Science and Technology Innovation Teams of Shanxi Province 202304051001041
6 · The paper itself

Abstract

Fluoride, an environmental toxicant, could induce endoplasmic reticulum stress (ERS) in neuronal cells ultimately leading to apoptosis and emotional dysfunction. Meanwhile, voluntary wheel running contributes to mitigate anxiety and depression. Our investigation aimed to study the effect of voluntary wheel running on anxiety- and depression-like behaviors in fluoride-exposure mice. The results showed that exposure to 100 mg/L sodium fluoride (NaF) for 6 months can induce anxiety- and depression-like behavior in mice. Fluorosis mice subjected to voluntary wheel running have less anxiety- and depression-like behaviors. Nissl and TUNEL staining demonstrated that fluoride led to a reduced proportion of Nissl body area in the cerebral cortex and an increased apoptotic ratio of nerve cells in the cerebral cortex. In contrast, these pathologic damages were improved in voluntary wheel running mice exposed to NaF. Moreover, the expressions of mRNA in the cerebral cortex GABA, GAD65, GAD67, DR, vGLU, 5-HT1A, BDNF, NMDAR1, and Bcl

Indexed as

AnxietyBehavior, AnimalDepressionFluoridesPhysical Conditioning, AnimalSodium FluorideAnimalsApoptosisEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressMaleMiceEndoplasmic Reticulum Chaperone BiPFluoridesHspa5 protein, mouseSodium FluorideAnxiety-depressionApoptosisEndoplasmic reticulum stressFluorideNeuroplasticityVoluntary wheel running

Identifiers

PMID39480623

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.