Evidence map›Paper›PMID 39481513›Full record

ArticleExperimental neurology2025

Regulation of wakefulness by neurotensin neurons in the lateral hypothalamus.

Fumito Naganuma, Mudasir Khanday, Sathyajit Sai Bandaru, Whidul Hasan, Kyosuke Hirano, Takeo Yoshikawa, Ramalingam Vetrivelan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hypothalamic control of arousal.Reviews in endocrine & metabolic disorders · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fumito NaganumaDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Mudasir KhandayDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States of America.
Sathyajit Sai BandaruDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Whidul HasanDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States of America.
Kyosuke HiranoDepartment of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Takeo YoshikawaDepartment of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Ramalingam VetrivelanDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States of America. Electronic address: vramalin@bidmc.harvard.edu.

Funding

Neural Mechanisms Underlying Cataplexy Control by MCH NeuronsR01NS119223 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RAMALINGAM, VETRIVELAN · 2021 to 2025
$2.2M
NINDS NIH HHS R01 NS119223
6 · The paper itself

Abstract

The lateral hypothalamic region (LH) has been identified as a key region for arousal regulation, yet the specific cell types and underlying mechanisms are not fully understood. While neurons expressing orexins (OX) are considered the primary wake-promoting population in the LH, their loss does not reduce daily wake levels, suggesting the presence of additional wake-promoting populations. In this regard, we recently discovered that a non-OX cell group in the LH, marked by the expression of neurotensin (Nts), could powerfully drive wakefulness. Activation of these Nts

Indexed as

Hypothalamic Area, LateralNeuronsNeurotensinWakefulnessAnimalsArousalElectroencephalographyMaleMiceMice, Inbred C57BLMice, TransgenicSleepNeurotensinArousalConditional ablationFiber photometryHypersomniaLocomotionNeurotensinOrexins

Identifiers

PMID39481513
PMCPMC11611607

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.