ArticleNature metabolism2024
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Abstract read
In one paragraph
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Exofacial Epitope-Specific Antibodies Detect GLUT4 Translocation in Adult Human, Rat, and Mouse Skeletal Muscle.Diabetes · 2026Article
- AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis.Nature metabolism · 2026Review
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Jonas M Kristensen *August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Rasmus Kjøbsted *August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0628-4994
Trine J LarsenGreenland Center of Health Research, Institute of Institute of Health and Nature, University of Greenland, Nuuk, Greenland.
Christian S CarlAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9551-5837
Janne R HingstAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Johan OnslevAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5143-9377
Jesper B BirkAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9775-4789
Anette ThorupAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Dorte E SteenbergAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Jonas R KnudsenAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5471-491X
Nicolai S HenriksenAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0009-0008-7647-5535
Elise J NeedhamCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Jens F HallingSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Anders GudiksenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Carsten F RundstenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristian E HanghøjThe Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Sara E StinsonNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1491-9179
Birgitte HoierAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Camilla C HansenAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2839-6150
Thomas E JensenAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6139-8268
Ylva HellstenAugust Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2435-9558
Henriette PilegaardSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1071-0327
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5526-1070
Jesper OlesenQueen Ingrid Primary Health Care Center, Nuuk, Greenland.
Sean J HumphreyCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-2666-9744
David E JamesCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-5946-5257
Michael L PedersenGreenland Center of Health Research, Institute of Institute of Health and Nature, University of Greenland, Nuuk, Greenland.
Erik A RichterAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6850-3056
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Marit E JørgensenGreenland Center of Health Research, Institute of Institute of Health and Nature, University of Greenland, Nuuk, Greenland.ORCID http://orcid.org/0000-0001-8356-5565
Jørgen F P WojtaszewskiAugust Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. jw@nexs.ku.dk.ORCID http://orcid.org/0000-0001-8185-3408
Funding
Det Frie Forskningsråd (Danish Council for Independent Research) #5053 00095BDet Frie Forskningsråd (Danish Council for Independent Research) #7016 00386BDet Frie Forskningsråd (Danish Council for Independent Research) #8020 00288BNovo Nordisk Fonden (Novo Nordisk Foundation) #NNF14OC0013057Novo Nordisk Fonden (Novo Nordisk Foundation) #NNF17OC0028136Novo Nordisk Fonden (Novo Nordisk Foundation) #NNF17SA0031406Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) #NNF18CC0034900
Abstract
In the Greenlandic Inuit population, 4% are homozygous carriers of a genetic nonsense TBC1D4 p.Arg684Ter variant leading to loss of the muscle-specific isoform of TBC1D4 and an approximately tenfold increased risk of type 2 diabetes
Indexed as
ExerciseGTPase-Activating ProteinsInsulin ResistanceMuscle, SkeletalAdultFemaleGlucose Tolerance TestGlucose Transporter Type 4HeterozygoteHumansInsulinMaleGlucose Transporter Type 4GTPase-Activating ProteinsInsulinTBC1D4 protein, human
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.