Evidence mapPaperPMID 39482793Full record

ReviewEye and vision (London, England)2024

A review of the application of in-vivo confocal microscopy on conjunctival diseases.

Mingyi Yu, Chang Liu, Jodhbir S Mehta, Yu-Chi Liu

Abstract readReview
In one paragraph

Review in Eye and vision (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025
    Review
  3. Article
  4. Conjunctival Venular Hemodynamic Biomarkers in Glaucoma.Translational vision science & technology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mingyi YuTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore.
Chang LiuTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore.
Jodhbir S MehtaTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore.
Yu-Chi LiuTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore. liuchiy@gmail.com.ORCID http://orcid.org/0000-0001-5408-0382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past few decades, the expanded applications of in-vivo confocal microscopy (IVCM) have greatly enhanced the knowledge of a variety of conjunctival diseases. IVCM allows non-invasively detailed observation of tarsal, palpebral and bulbar conjunctiva, from the superficial to the substantia propria at the cellular level. IVCM has been shown as a powerful tool for the assessment of morphological changes in both physiological and pathological conditions. High-resolution images of different cellular phenotypes, together with quantifiable results, open new insights into understanding the mechanisms of conjunctival diseases, as well as provide valuable and longitudinal information for the diagnosis and therapeutic evaluation. This review aims to provide an overview of the current knowledge on the applications of IVCM on conjunctival disorders, including aging changes, dry eye-related morphological changes, glaucoma and glaucoma surgery-related morphological changes, conjunctival neoplasm, pterygium, allergic conjunctivitis, trachomatous scarring, and the conjunctiva-associated lymphoid tissue (CALT) changes. In this review, we highlight the key findings of previous studies and discusses the current limitations and challenges of IVCM in assessing the structural characteristics of the conjunctiva. Furthermore, we consider possible future directions for unlocking the full potential of IVCM applications. The insights presented here will contribute to a more comprehensive understanding of the applications of IVCM in conjunctival diseases.

Indexed as

ConjunctivaConjunctival diseaseIn-vivo confocal microscopyOcular surface

Identifiers

PMID39482793
PMCPMC11529254

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.