Evidence map›Paper›PMID 39482843›Full record

ArticlePhysiological reports2024

Intrauterine growth-restricted pregnant rats, from placental ischemic dams, display preeclamptic-like symptoms: A new rat model of preeclampsia.

Jonna Smith, Madison Powell, Whitney Cromartie, Savanna Smith, Kylie Jones, Angie Castillo, Jordan Shaw, Joseph Editone, Ahfiya Howard, Robert Tatum and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jonna SmithDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Madison PowellDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Whitney CromartieDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Savanna SmithDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Kylie JonesDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Angie CastilloDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Jordan ShawDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Joseph EditoneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Ahfiya HowardSchool of Social Work, Texas A & M University-Commerce, Commerce, Texas, USA.
Robert TatumDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Alex SmithDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Brandon FisherDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
George W BoozDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Mark CunninghamDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.ORCID 0000-0002-6852-4375

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
American Heart Association (AHA) 18CDA34110264Foundation for the National Institutes of Health (FNIH) P20GM121334NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Preeclampsia (PE) is characterized by de novo hypertension (HTN) and is often associated with intrauterine growth restriction (IUGR). Hallmarks of PE are placental ischemia, decreased nitric oxide (NO) bioavailability, oxidative stress (OS), and organ damage in the kidneys and brain. This study aims to characterize a new model of PE using pregnant IUGR rats from hypertensive placental ischemic dams. It is hypothesized that pregnant IUGR rats from hypertensive placental ischemic dams will have elevated blood pressure (BP), OS, and organ damage. In this study, pregnant rats are divided into two groups: normal pregnant (NP) and hypertensive placental ischemic dams (RUPP). Offspring from NP and RUPP dams were mated at 10 weeks of age to generate pregnant IUGR (IUGR Preg) and pregnant control (CON Preg) rats. BP and other markers of PE were evaluated during late gestation. Pregnant IUGR rats had elevated BP and systemic OS. The maternal body weight of pregnant IUGR rats and their pups' weights were decreased, while the brains were enlarged with elevated OS. In summary, pregnant IUGR rats, born from hypertensive placental ischemic dams, have HTN and increased systemic and brain OS, with larger brain sizes and smaller pups. Furthermore, this study shows that pregnant IUGR rats exhibit a preeclamptic-like phenotype, suggesting a new epigenetic model of PE.

Indexed as

Disease Models, AnimalFetal Growth RetardationPlacentaPre-EclampsiaAnimalsBlood PressureBrainFemaleIschemiaOxidative StressPregnancyRatsRats, Sprague-Dawleyhypertensionintrauterine growth restriction (IUGR)nitric oxideoxidative stresspreeclampsia

Identifiers

PMID39482843
PMCPMC11527824

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.