Evidence map›Paper›PMID 39482899›Full record

ArticleJournal of oral rehabilitation2025

Genome-Wide Association Study of Temporomandibular Disorder-Related Pain in Finnish Populations.

J M Leppilahti, J Knuutila, P Pesonen, V Vuollo, M Männikkö, M K Karjalainen, A L Suominen, K Sipilä

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J M LeppilahtiResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0002-0901-7189
J KnuutilaResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
P PesonenNorthern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.
V VuolloResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
M MännikköNorthern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.
M K KarjalainenResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
A L SuominenInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.
K SipiläResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0001-9734-320X

Funding

Academy of FinlandEuropean Regional Development FundOulun YliopistoOulun Yliopistollinen SairaalaRegional institute of Occupational Health, Oulu, FinlandSosiaali- ja TerveysministeriöSuomen HammaslääkäriliittoSuomen Hammaslääkäriseura ApolloniaTerveyden ja hyvinvoinnin laitos
6 · The paper itself

Abstract

backgroundTemporomandibular disorders (TMD) are multifactorial musculoskeletal pain and dysfunctions in temporomandibular joints (TMJs) and masticatory muscles. Genetic factors play a role in TMD-related pain, but only a few genome-wide association studies (GWAS) have been conducted.

objectiveThe aim of this GWAS was to explore genetic factors associated with painful TMD in Finnish populations.

methodsData from two epidemiological surveys, the Northern Finland Birth Cohort 1966 (NFBC1966) and the Health 2000 Survey in Finland, including altogether 468 cases and 6833 controls, were used. Case definition was based on pain on palpation of masticatory muscles and/or TMJs. GWASs of the whole data and stratified by sex were conducted from both cohorts using additive models, followed by meta-analysis of the two cohorts. Replications of the previously reported TMD risk loci (rs73460075, DMD; rs4794106, SGCA; rs73271865, SP4; rs60249166, RXP2; rs1531554, BAHCCI; rs5862730, OTUD4/SMAD1; rs10092633, SFRP1; rs34612513, SOX14/CLDN18; rs878962, TSPAN9) were also investigated.

resultsFour genome-wide significant loci were found in sex-stratified analysis of NFBC1966, including associations at three loci in males (rs1023114, PRIM2, p = 5 × 10

conclusionSeveral TMD pain-associated variants were found in sex-stratified analysis of NFBC1966, suggesting the role of neuroendocrine stress responses and central nervous system. These findings need to be confirmed in future studies.

Indexed as

Facial PainGenome-Wide Association StudyTemporomandibular Joint DisordersAdultCase-Control StudiesFemaleFinlandGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single Nucleotidebirth cohort studieschronic paingenome‐wide association studymyalgiapublic health surveillancetemporomandibular joint disorders

Identifiers

PMID39482899
PMCPMC11740273

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.