Evidence map›Paper›PMID 39482909›Full record

SynthesisCurrent neuropharmacology2025

Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load.

Roberta Zupo, Fabio Castellana, Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Roberta Tardugno, Nicola Cicero, Filomena Corbo, Pasquale Crupi, Rodolfo Sardone and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Roberta ZupoDepartment of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70100 Bari, Italy.
Fabio CastellanaDepartment of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70100 Bari, Italy.
Francesco PanzaDepartment of Interdisciplinary Medicine (DIM), "Cesare Frugoni" Internal and Geriatric Medicine and Memory Unit, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70100 Bari, Italy.
Vincenzo SolfrizziDepartment of Interdisciplinary Medicine (DIM), "Cesare Frugoni" Internal and Geriatric Medicine and Memory Unit, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70100 Bari, Italy.
Madia LozuponeDepartment of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari Aldo Moro, Bari, Italy.
Roberta TardugnoDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Nicola CiceroDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98168 Messina, Italy.
Filomena CorboDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Pasquale CrupiDepartment of Agricultural, Food and Forest Science, University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.
Rodolfo SardoneUnit of Statistics and Epidemiology, Local Health Authority of Taranto, Taranto, Italy.
Maria Lisa ClodoveoDepartment of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70100 Bari, Italy.

Funding

Ministry of Health PNRR-MAD-2022- 12376656
6 · The paper itself

Abstract

backgroundMediterranean diet may enhance cognitive function and delay the progression of Alzheimer's disease (AD). We conducted a systematic review to investigate the effect of oleocanthal (OC) from extra-virgin olive oil (EVOO) on amyloid-β (Aβ) burden in preclinical models of AD, considering the anti-inflammatory and neuroprotective effects of EVOO biophenols, which are key components of the Mediterranean dietary model.

methodsThe literature was searched through six electronic databases until February 2023. Screening of 52 retrieved articles for inclusion criteria resulted in 7 preclinical reports evaluating the effect of an OC-supplemented diet on AD trajectories by means of Aβ load or clearance in affected models. Reports were appraised for risk of bias using the SYRCLE's RoB tool. A protocol was registered on PROSPERO.

resultsCase control prevailed over the case-crossover design, and the geographical distribution was uniformly American. The study population mostly included 5xFAD, otherwise TgSwDI or wild-type C57BL/6 mouse models. We found a role of OC in reducing Aβ load in the hippocampal parenchyma and microvessels compared with controls. An increased cerebral clearance of Aβ through the bloodbrain barrier and a substantial improvement in metabolic and behavioral parameters were also reported in preclinical models under an OC-enriched diet. The risk of bias was shown to be moderate overall.

conclusionPreclinical data are promising about the effects of OC from the Mediterranean diet's EVOO in relieving the burden of Aβ in AD; however, further evidence is needed to corroborate the efficacy of this biophenol and strengthen the speculated causal pathway.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCyclopentane MonoterpenesOlive OilPolyphenolsAldehydesAnimalsDiet, MediterraneanDisease Models, AnimalHumansMicePhenolsAldehydesAmyloid beta-PeptidesCyclopentane MonoterpenesoleocanthalOlive OilPhenolsPolyphenolsAlzheimer’s diseaseamyloid-βbiophenololecanthalOlive oil polyphenolspreclinical studiessystematic review.

Identifiers

PMID39482909
PMCPMC12307993

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.