Translation of Deoxyribonucleic Acid into Synthetic Alpha Helical Peptides for Darwinian Evolution.

Millicent Dockerill, Pramod M Sabale, Francesco Russo, Sofia Barluenga, Nicolas Winssinger

Abstract read

In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Sequencing of d/l-DNA and XNA by Templated-Synthesis.Journal of the American Chemical Society · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Millicent DockerillDepartment of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva 1211, Switzerland.ORCID https://orcid.org/0000-0003-4657-1637

Pramod M SabaleDepartment of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva 1211, Switzerland.ORCID https://orcid.org/0000-0002-7291-6697

Francesco RussoDepartment of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva 1211, Switzerland.

Sofia BarluengaDepartment of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva 1211, Switzerland.

Nicolas WinssingerDepartment of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva 1211, Switzerland.ORCID https://orcid.org/0000-0003-1636-7766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-encoded libraries connect the phenotypes of synthetic molecules to a DNA barcode; however, most libraries do not tap into the potential of Darwinian evolution. Herein, we report a DNA-templated synthesis (DTS) architecture to make peptides that are stabilized into α-helical conformations via head-to-tail supramolecular cyclization. Using a pilot library targeting MDM2, we show that repeated screening can amplify a binder from the lowest abundance in the library to a ranking that correlates to binding affinity. The study also highlights the need to design libraries such that the chemistry avoids biases from the heterogeneous yield in DTS.

Identifiers

PMID39483244

DOI10.1021/jacsau.4c00738

PMCPMC11522901

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.