ReviewFrontiers in immunology2024
Unveiling the multifaceted role of toll-like receptors in immunity of aquatic animals: pioneering strategies for disease management.
Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context.Frontiers in immunology · 2025Pooled it
- Transcriptomic and Proteomic Insights into Mucosal Immune Responses of Asian Seabass (International journal of molecular sciences · 2026Article
- Combined effects of dietary ellagic acid and Bacillus coagulans on growth performance, antioxidant and immune responses, intestinal health, and resistance to Streptococcus agalactiae in striped catfish.Veterinary research communications · 2026Article
- Therapeutic and immunomodulatory effects of phage therapy in red hybrid tilapia challenged with Klebsiella pneumoniae.Archives of microbiology · 2026Article
- Effects of Fermented Longan Peel (Antioxidants (Basel, Switzerland) · 2026Article
- Absence of Toll-like Receptor 21 (Biology · 2026Article
- Toll-like receptors in fish: evolution, structure, immune signaling, and translational prospects for adjuvant-based vaccine design in aquaculture.Frontiers in immunology · 2026Review
- Long-Term Heat Stress Triggers Immune Activation and Cell Death Remodeling in the Brain of Largemouth Bass (Animals : an open access journal from MDPI · 2025Article
- Report on Vibrio Species Contamination in Shrimp From the Coast of Pangandaran, West Java, Indonesia.Environmental microbiology reports · 2025Article
- Structural and Functional Characteristics of TLR19 in Barbel Chub Compared to TLR19 in Grass Carp.International journal of molecular sciences · 2025Article
- Natterin bridges IFN-φ1 and non-canonical inflammasome pathways viaFrontiers in cellular and infection microbiology · 2025Article
- Single-cell transcriptomics unveils leukocyte heterogeneity in the gills ofFrontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern recognition receptor (PRR), which drives innate immunity, shields the host against invasive pathogens. Fish and other aquatic species with poorly developed adaptive immunity mostly rely on their innate immunity, regulated by PRRs such as inherited-encoded toll-like receptors (TLRs). The discovery of 21 unique TLR variations in various aquatic animals over the past several years has sparked interest in using TLRs to improve aquatic animal's immune response and disease resistance. This comprehensive review provides an overview of the latest investigations on the various characteristics of TLRs in aquatic animals. It emphasizes their categorization, insights into 3D architecture, ligand recognition, signaling pathways, TLRs mediated immune responses under biotic and abiotic stressors, and expression variations during several developmental stages. It also highlights the differences among aquatic animals' TLRs and their mammal counterparts, which signifies the unique roles that TLRs play in aquatic animal's immune systems. This article summarizes current aquaculture research to enhance our understanding of fish immune systems for effective aquaculture -related disease management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.