Evidence map›Paper›PMID 39483718›Full record

ReviewAsian journal of pharmaceutical sciences2024

Extracellular vesicle-functionalized bioactive scaffolds for bone regeneration.

Taozhao Yu, Irene Shuping Zhao, Hongguang Pan, Jianhua Yang, Huanan Wang, Yongqiang Deng, Yang Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Asian journal of pharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taozhao YuSchool of Dentistry, Shenzhen University Medical School, Shenzhen 518015, China.
Irene Shuping ZhaoSchool of Dentistry, Shenzhen University Medical School, Shenzhen 518015, China.
Hongguang PanDepartment of Otolaryngology, Shenzhen Children Hospital, Shenzhen 518034, China.
Jianhua YangLonggang District People's Hospital of Shenzhen & The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen 518172, China.
Huanan WangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Yongqiang DengSchool of Dentistry, Shenzhen University Medical School, Shenzhen 518015, China.
Yang ZhangSchool of Dentistry, Shenzhen University Medical School, Shenzhen 518015, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions. Among emerging strategies, extracellular vesicles (EVs) have shown promise as an acellular approach for bone regeneration. However, their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection. To address this challenge, EV-functionalized scaffolds have recently been proposed as an alternative delivery strategy to enhance EV retention and subsequent healing efficacy. This review aims to consolidate recent advancements in the development of EV-functionalized scaffolds for augmenting bone regeneration. It explores various sources of EVs and different strategies for integrating them into biomaterials. Furthermore, the mechanisms underlying their therapeutic effects in bone regeneration are elucidated. Current limitations in clinical translation and perspectives on the design of more efficient EVs for improved therapeutic efficacy are also presented. Overall, this review can provide inspiration for the development of novel EV-assisted grafts with superior bone regeneration potential.

Indexed as

BiomaterialsBone regenerationExosomesExtracellular vesiclesLocal delivery

Identifiers

PMID39483718
PMCPMC11525715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.