Evidence map›Paper›PMID 39483871›Full record

ArticleResearch square2024

Cytosolic Phospholipase A2 in Infiltrating Monocyte-Derived Macrophages Does Not Impair Recovery After Spinal Cord Injury in Female Mice.

Ethan P Glaser, Timothy J Kopper, William M Bailey, Reena Kumari, Hassan K Kashif, Andrew N Stewart, John C Gensel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ethan P GlaserUniversity of Kentucky College of Medicine.
Timothy J KopperUniversity of Colorado Anschutz Medical Campus.
William M BaileyUniversity of Kentucky College of Medicine.
Reena KumariUniversity of Kentucky College of Medicine.
Hassan K KashifUniversity of Kentucky College of Medicine.
Andrew N StewartUniversity of Kentucky College of Medicine.
John C GenselUniversity of Kentucky College of Medicine.

Funding

Macrophage Depletion Therapy for Spinal Cord InjuryR01NS116068 · NINDS · UNIVERSITY OF KENTUCKY · PI ALILAIN, WARREN JOSEPH, GENSEL, JOHN C · 2021 to 2025
$3.0M
The Role of Perilipin 2 in Macrophages after Experimental Spinal Cord InjuryF30NS129251 · NINDS · UNIVERSITY OF KENTUCKY · PI GLASER, ETHAN PHARES · 2022 to 2023
$104k
Contributions of Myelin Derived Arachidonic Acid to Macrophage Polarization and Secondary Damage after Spinal Cord InjuryF31NS105443 · NINDS · UNIVERSITY OF KENTUCKY · PI KOPPER, TIMOTHY JOSEPH · 2018 to 2020
$90k
NINDS NIH HHS F30 NS129251NINDS NIH HHS F31 NS105443NINDS NIH HHS R01 NS116068
6 · The paper itself

Abstract

Spinal cord injury (SCI) leads to permanent motor and sensory loss that is exacerbated by intraspinal inflammation that persists months to years after injury. After SCI, monocyte-derived macrophages (MDMs) infiltrate the lesion to aid in myelin-rich debris clearance. During debris clearance, MDMs adopt a proinflammatory phenotype that exacerbates neurodegeneration and hinders recovery. The underlying cause of the lipid-mediated MDM phenotype shift is unclear. Our previous work suggests that cytosolic phospholipase A2 (cPLA2) plays a role in the proinflammatory potentiating effect of myelin on macrophages

Indexed as

Cytosolic phospholipase A2inflammationmacrophagemyelinSpinal cord injury

Identifiers

PMID39483871
PMCPMC11527225

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.