Evidence map›Paper›PMID 39484239›Full record

ArticlemedRxiv : the preprint server for health sciences2024

DO NOT LOSE SLEEP OVER IT: IMPLANTED BRAIN-COMPUTER INTERFACE FUNCTIONALITY DURING NIGHTTIME IN LATE-STAGE AMYOTROPHIC LATERAL SCLEROSIS.

Sacha Leinders, Erik J Aarnoutse, Mariana P Branco, Zac V Freudenburg, Simon H Geukes, Anouck Schippers, Malinda S W Verberne, Max van den Boom, Benny van der Vijgh, Nathan E Crone and 3 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02224469 (Utrecht Neural Prosthesis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02224469 nacompletednot on this map

Utrecht Neural Prosthesis (UNP): A Pilot Study on Controllability of Brain Signals and Application in locked-in Patients

TypeinterventionalSponsorUMC UtrechtRan2015 to 2024Enrolled6ConditionsLocked-In SyndromeArmsECoG (electrocorticography) sensing
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sacha LeindersUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Erik J AarnoutseUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Mariana P BrancoUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Zac V FreudenburgUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Simon H GeukesUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Anouck SchippersUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Malinda S W VerberneUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Max van den BoomUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Benny van der VijghUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Nathan E CroneDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA.
Timothy DenisonMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Nick F RamseyUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
Mariska J VansteenselUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.ORCID 0000-0002-9252-5116

Funding

Investigation of the Cortical Communication (CORTICOM) SystemUH3NS114439 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CRONE, NATHAN E, RAMSEY, NICOLAS FRANCISCUS · 2020 to 2025
$6.6M
Brain-Computer Interface Implant for Severe Communication DisabilityU01DC016686 · NIDCD · UNIVERSITY MEDICAL CENTER UTRECHT · PI CRONE, NATHAN E, RAMSEY, NICOLAS FRANCISCUS · 2018 to 2021
$2.5M
NIDCD NIH HHS U01 DC016686NINDS NIH HHS UH3 NS114439
6 · The paper itself

Abstract

Background and objectives: Brain-computer interfaces ( Methods: We investigated nocturnal dynamics of neural signal features used for BCI control, namely low ( Results: Power and variance in HFB and LFB were significantly higher at night than during the day in the majority of the nights, with HFB variance being higher in 88% of nights. Daytime decoders caused 245 unintended selection-clicks and 13 unintended caregiver-calls per hour when applied to night data. The developed nightmode decoder functioned error-free in 79% of nights over a period of ±1.5 years, allowing the user to reliably call the caregiver, with unintended activations occurring only once every 12 nights. Discussion: Reliable nighttime use of a BCI requires decoders that are adjusted to sleep-related signal changes. This demonstration of a reliable BCI nightmode and its long-term use by an individual with advanced ALS underscores the importance of 24/7 BCI reliability. Trial registration: This trial is registered in clinicaltrials.gov under number NCT02224469 (https://clinicaltrials.gov/study/NCT02224469?term=NCT02224469&rank=1). Date of submission to registry: August 21, 2014. Enrollment of first participant: September 7, 2015.

Identifiers

PMID39484239
PMCPMC11527056

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.