ArticlemedRxiv : the preprint server for health sciences2024
Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder.
Alex P Miller, Kellyn M Spychala, Wendy S Slutske, Kim Fromme, Ian R Gizer
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
5 authors.
Alex P MillerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID 0000-0001-9163-8947 Kellyn M SpychalaDepartment of Psychological Sciences, University of Missouri, Columbia, MO, United States.ORCID 0000-0001-9046-6848 Wendy S SlutskeCenter for Tobacco Research and Intervention, Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.ORCID 0000-0003-4502-6936 Ian R GizerDepartment of Psychological Sciences, University of Missouri, Columbia, MO, United States.ORCID 0000-0002-4026-5674 Funding
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VII Core ProjectU01AG071448 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER · 2021 to 2026
$40.2MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia ProjectU01AG071450 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HUMMER, ROBERT A · 2021 to 2025
$16.2MTransdisciplinary Training in Addictions ResearchT32DA015035 · NIDA · WASHINGTON UNIVERSITY · PI Leopoldo J Cabassa, Patricia A Cavazos-Rehg · 2002 to 2026
$5.3MAlcohol and Behavioral Risks Throughout CollegeR01AA013967 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI FROMME, KIM · 2003 to 2009
$3.3MPathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyR01AA018333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M, KENDLER, KENNETH SEEDMAN · 2010 to 2014
$2.8MGenetic Mechanisms of Change in Trajectories of Drinking and Deviant BehaviorsR01AA020637 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FROMME, KIM · 2012 to 2016
$2.3MNeurogenetic influences linking impulsive personality traits and alcohol use disorder progression across developmentK01AA031724 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI Alex Parker Miller · 2024 to 2026
$548kRelations between alcohol use, aggression, executive function, and ADHD: a genetic analysisF31AA029948 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI SPYCHALA, KELLYN M · 2022 to 2023
$94kMultivariate analyses of polygenic risk for impulsivity and alcohol use: A study of longitudinal trajectories of binge drinking in emerging adulthoodF31AA027957 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI MILLER, ALEX PARKER · 2019 to 2022
$77kNIAAA NIH HHS F31 AA027957NIAAA NIH HHS F31 AA029948NIAAA NIH HHS K01 AA031724NIAAA NIH HHS R01 AA013967NIAAA NIH HHS R01 AA018333NIAAA NIH HHS R01 AA020637NIA NIH HHS U01 AG071448NIA NIH HHS U01 AG071450NICHD NIH HHS P01 HD031921NIDA NIH HHS T32 DA015035Wellcome Trust
6 · The paper itselfAbstract
Binge drinking is a relatively common pattern of alcohol use among youth with normative frequency trajectories peaking in emerging and early adulthood. Frequent binge drinking is a critical risk factor for not only the development of alcohol use disorders (AUDs) but also increased odds of alcohol-related injury and death, and thus constitutes a significant public health concern. Changes in binge drinking across development are strongly associated with changes in impulsive personality traits (IPTs) which have been hypothesized as intermediate phenotypes associated with genetic risk for heavy alcohol use and AUD. The current study sought to examine the extent to which longitudinal changes in binge drinking and intoxication frequency across adolescence and early adulthood are associated with genetic influences underlying dual-systems IPTs (i.e., top-down [lack of self-control] and bottom-up [sensation seeking and urgency] constructs) alongside genetic risk for alcohol consumption and AUD. Associations were tested using conditional latent growth curve polygenic score (PGS) models in three independent longitudinal samples (
Indexed as
binge drinkingdevelopmentdual-systemsimpulsive personality traitspolygenic scores
Identifiers
PMID39484268
PMCPMC11527070
What Socratic holds
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