Evidence map›Paper›PMID 39484384›Full record

ArticlebioRxiv : the preprint server for biology2024

Aerobic capacity and exercise mediate protection against hepatic steatosis via enhanced bile acid metabolism.

Benjamin A Kugler, Adrianna Maurer, Xiaorong Fu, Edziu Franczak, Nick Ernst, Kevin Schwartze, Julie Allen, Tiangang Li, Peter A Crawford, Lauren G Koch and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Benjamin A KuglerDepartments of Cell Biology and Physiology.ORCID 0000-0003-0822-7106
Adrianna MaurerDepartments of Cell Biology and Physiology.
Xiaorong FuCenter for Human Nutrition and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Edziu FranczakDepartments of Cell Biology and Physiology.
Nick ErnstDepartments of Cell Biology and Physiology.
Kevin SchwartzeDepartments of Cell Biology and Physiology.ORCID 0000-0003-4577-8345
Julie AllenDepartments of Cell Biology and Physiology.
Tiangang LiDepartment of Biochemistry and Physiology, and Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Peter A CrawfordDivision of Molecular Medicine, Department of Medicine, and Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN.
Lauren G KochDept of Physiology and Pharmacology, The University of Toledo, Toledo, OH, USA.
Steven L BrittonDept of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Shawn C BurgessCenter for Human Nutrition and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John P ThyfaultDepartments of Cell Biology and Physiology.

Funding

longitudinal assessment of stress and stress-related concepts across a behavioral weight loss interventionP20GM144269 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Ilce Gabriela Medina-Meza, John P Thyfault · 2022 to 2026
$14.9M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Factors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8M
Regulation of Bile Acid Metabolism and Signaling in Metabolic DiseasesR01DK117965 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Tiangang Li · 2019 to 2026
$2.7M
Ketogenic Oscillations and Neurometabolic HealthspanR01AG069781 · NIA · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, THYFAULT, JOHN P · 2020 to 2024
$2.3M
Divergence in Aerobic Capacity Drives Liver and Brain HealthR01DK121497 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2019 to 2022
$2.2M
Regulation of lipogenesis by TCA cycle metabolismR01DK128168 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2021 to 2025
$2.1M
Sulfur Amino Acid Metabolism and Regulation of Hepatic Metabolic FlexibilityR01DK131064 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LI, TIANGANG · 2022 to 2025
$1.6M
Translating Obesity, Metabolic Dysfunction and Comorbid Disease StatesT32DK128770 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John P Thyfault, Douglas E Wright · 2022 to 2026
$806k
Sexual dimorphism, hepatic mitochondrial adaptations, and hepatic steatosisI01BX002567 · VA · KANSAS CITY VA MEDICAL CENTER · PI THYFAULT, JOHN P · 2015 to 2025
–
BLRD VA I01 BX002567NIA NIH HHS R01 AG069781NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK078184NIDDK NIH HHS R01 DK117965NIDDK NIH HHS R01 DK121497NIDDK NIH HHS R01 DK128168NIDDK NIH HHS R01 DK131064NIDDK NIH HHS T32 DK128770NIGMS NIH HHS P20 GM144269
6 · The paper itself

Abstract

High cardiorespiratory fitness and exercise show evidence of altering bile acid (BA) metabolism and are known to protect or treat diet-induced hepatic steatosis, respectively. Here, we tested the hypothesis that high intrinsic aerobic capacity and exercise both increase hepatic BA synthesis measured by the incorporation of

Indexed as

cholesterol synthesisCyp7a1de novo lipogenesislivermetabolismnon-alcoholic fatty liver disease

Identifiers

PMID39484384
PMCPMC11526936

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.