Evidence map›Paper›PMID 39484433›Full record

ArticlebioRxiv : the preprint server for biology2024

Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff disease.

Kate I Tsourmas, Claire A Butler, Nellie E Kwang, Zachary R Sloane, Koby J G Dykman, Ghassan O Maloof, Christiana A Prekopa, Robert P Krattli, Sanad M El-Khatib, Vivek Swarup and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kate I TsourmasDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.ORCID 0000-0001-8588-501X
Claire A ButlerDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.ORCID 0000-0001-9320-8297
Nellie E KwangDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.ORCID 0000-0001-8890-4976
Zachary R SloaneDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.
Koby J G DykmanDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.
Ghassan O MaloofDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.
Christiana A PrekopaDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.
Robert P KrattliDepartment of Anatomy and Neurobiology; University of California; Irvine, CA 92697; USA.ORCID 0000-0002-8911-5984
Sanad M El-KhatibDepartment of Anatomy and Neurobiology; University of California; Irvine, CA 92697; USA.ORCID 0000-0002-1697-2264
Vivek SwarupDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.ORCID 0000-0003-3762-2746
Munjal M AcharyaDepartment of Anatomy and Neurobiology; University of California; Irvine, CA 92697; USA.ORCID 0000-0002-7767-5642
Lindsay A HohsfieldDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.ORCID 0000-0002-6018-656X
Kim N GreenDepartment of Neurobiology and Behavior; University of California; Irvine, CA 92697; USA.

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Craig E Stark · 2017 to 2026
$71.9M
Origins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brainR01NS083801 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2014 to 2026
$5.6M
Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Microglia are necessary for cortical plaque formation in Alzheimer's diseaseRF1AG056768 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI GREEN, KIM · 2018 to 2018
$2.7M
Role of Disease-Associated Microglia in Alzheimer's diseaseR01AG081599 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2024 to 2026
$2.3M
Neuroimmunology Training Program at the University of California, IrvineT32NS121727 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, Thomas E Lane · 2022 to 2026
$854k
Summer Medical student Aging and Alzheimer disease Research Training (SMAART) programT35AG076424 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2022 to 2026
$361k
NIA NIH HHS R01 AG081599NIA NIH HHS RF1 AG056768NIA NIH HHS T35 AG076424NIA NIH HHS U54 AG054349NINDS NIH HHS R01 NS083801NINDS NIH HHS T32 NS082174NINDS NIH HHS T32 NS121727
6 · The paper itself

Abstract

Lysosomal storage disorders (LSDs) are a large disease class involving lysosomal dysfunction, often resulting in neurodegeneration. Sandhoff disease (SD) is an LSD caused by a deficiency in the β subunit of the β-hexosaminidase enzyme (

Identifiers

PMID39484433
PMCPMC11526954

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.