Evidence map›Paper›PMID 39484454›Full record

ArticlebioRxiv : the preprint server for biology2024

Olduvai domain expression downregulates mitochondrial pathways: implications for human brain evolution and neoteny.

Jonathon G Keeney, David Astling, Vanessa Andries, Karl Vandepoele, Nathan Anderson, Jonathan M Davis, Pamela Lopert, Jonathan Vandenbussche, Kris Gevaert, An Staes and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jonathon G KeeneyDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
David AstlingDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Vanessa AndriesInflammation Research Center, VIB, Ghent, Belgium.
Karl VandepoeleInflammation Research Center, VIB, Ghent, Belgium.
Nathan AndersonDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jonathan M DavisDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Pamela LopertDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jonathan VandenbusscheDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.
Kris GevaertDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.
An StaesDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.
Natasia PaukovichDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Beat VögeliDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kenneth L JonesDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Frans van RoyInflammation Research Center, VIB, Ghent, Belgium.
Manisha PatelDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
James M SikelaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Funding

SUPEROXIDE RADICALS IN SEIZURE-INDUCED NEURONAL DEATHR01NS039587 · NINDS · UNIVERSITY OF COLORADO DENVER · PI PATEL, MANISHA N · 2000 to 2019
$5.9M
Investigation of DUF1220 Domains in Human Brain Function and DiseaseR01MH081203 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SIKELA, JAMES M · 2009 to 2013
$2.0M
Investigation of DUF1220 domains in human brain function and diseaseR01MH108684 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SIKELA, JAMES M · 2016 to 2020
$1.9M
Molecular recognition by ADAR1 of Z-RNA within transcriptomesR01GM150642 · NIGMS · UNIVERSITY OF HOUSTON · PI Quentin Vicens, Beat Rolf Vogeli · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM150642NIMH NIH HHS R01 MH081203NIMH NIH HHS R01 MH108684NINDS NIH HHS R01 NS039587
6 · The paper itself

Abstract

Encoded by the NBPF gene family, Olduvai (formerly DUF1220) protein domains have undergone the largest human lineage-specific copy number expansion of any coding region in the genome. Olduvai copy number shows a linear relationship with several brain size-related measures and cortical neuron number among primates and with normal and disease-associated (micro- and macrocephaly) variation in brain size in human populations. While Olduvai domains have been shown to promote proliferation of neural stem cells, the mechanism underlying such effects has remained unclear. Here, we investigate the function of Olduvai by transcriptome and proteome analyses of cells overexpressing

Identifiers

PMID39484454
PMCPMC11526873

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.