Evidence map›Paper›PMID 39485576›Full record

ArticleCellular and molecular neurobiology2024

Pesticide Exposure and Its Association with Parkinson's Disease: A Case-Control Analysis.

Ali Samareh, Hossein Pourghadamyari, Mohammad Hadi Nemtollahi, Hossein Ali Ebrahimi Meimand, Mohammad Erfan Norouzmahani, Gholamreza Asadikaram

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In one paragraph

Article in Cellular and molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ali SamarehApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.ORCID https://orcid.org/0000-0002-1234-7904
Hossein PourghadamyariApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.ORCID https://orcid.org/0000-0002-4969-8572
Mohammad Hadi NemtollahiApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.ORCID https://orcid.org/0000-0002-9529-4077
Hossein Ali Ebrahimi MeimandNeurology Research Center, Kerman University of Medical Sciences, Kerman, Iran. Hebrahimi@kmu.ac.ir.ORCID https://orcid.org/0000-0001-6088-6120
Mohammad Erfan NorouzmahaniDepartment of Clinical Biochemistry, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Gholamreza AsadikaramApplied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran. Gh_asadi@kmu.ac.ir.ORCID https://orcid.org/0000-0002-9100-0756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a complex disorder that arises from genetic and environmental factors. The current investigation endeavors to investigate the role of exposure to organochlorine (OCPs) and organophosphate pesticides (OPPs), recognized as the main environmental elements, in the genesis of PD. In this case-control study, 29 PD patients and 51 healthy subjects were involved. Gas chromatography was performed to measure the serum levels of organochlorine chemicals (2,4-DDT, 4,4-DDT, 2,4-DDE, 4,4-DDE, α-HCH, β-HCH, and γ-HCH). Furthermore, acetylcholinesterase (AChE) activity, arylesterase activity of paraoxonase-1 (PON-1), and several oxidative stress (OS) markers were assessed. The levels of OCPs in the PD patients were significantly higher than in the control subjects. In addition, AChE activity, arylesterase activity of PON-1, catalase activity, and superoxide dismutase 3 activity in PD patients were significantly less than controls. However, the levels of carbonyl protein, total antioxidant capacity, malondialdehyde, and nitric oxide in PD patients were higher than the controls. The findings of this investigation have indicated that OCPs and OPPs exposure could contribute to the development of Parkinson's disease. This potential linkage could either be established through the direct impact of these pesticides on the nervous system, leading to neurotoxicity, or via an indirect route through the triggering of OS.

Indexed as

AcetylcholinesteraseAryldialkylphosphataseParkinson DiseasePesticidesAgedCase-Control StudiesEnvironmental ExposureFemaleHumansHydrocarbons, ChlorinatedMaleMiddle AgedOxidative StressAcetylcholinesteraseAryldialkylphosphataseHydrocarbons, ChlorinatedPesticidesPON1 protein, humanOrganochlorine pesticidesOrganophosphate pesticidesOxidative stressParkinson’s diseasePesticide exposure

Identifiers

PMID39485576
PMCPMC11530492

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.