Evidence map›Paper›PMID 39485719›Full record

ReviewCancer communications (London, England)2025

Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms.

Jiali Yao, Linlin Ji, Guang Wang, Jin Ding

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer communications (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiali YaoClinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, China.
Linlin JiClinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, China.
Guang WangClinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, China.
Jin DingClinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0001-7183-4609

Funding

Innovation Program of Shanghai Municipal Education Commission 20230548Medical Discipline Construction Project of Pudong Health Committee of Shanghai PWYgf2021-08National Natural Science Foundation of China 82303184National Natural Science Foundation of China 82473431Shanghai Key Laboratory of Cell Engineering 14DZ2272300
6 · The paper itself

Abstract

Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel classification and phenotypes of neutrophils and describe the regulatory relationships between neutrophils and tumor metabolism, flora microecology, neuroendocrine and tumor therapy from a new perspective. Secondly, we review the mechanisms by which neutrophils affect drug resistance in tumor immunotherapy from the aspects of the immune microenvironment, tumor antigens, and epigenetics. Finally, we propose several promising strategies for overcoming tumor immunotherapy resistance by targeting neutrophils and provide new research ideas in this area.

Indexed as

Drug Resistance, NeoplasmImmunotherapyNeoplasmsNeutrophilsAnimalsHumansTumor Microenvironmentimmune resistanceimmunotherapyneutrophiltumorTumor microenvironment

Identifiers

PMID39485719
PMCPMC11758154

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.