Evidence map›Paper›PMID 39485795›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.

Yu Hua, Jianxiu Zhang, Man-Yun Yang, Fan-Yi Zhang, Jing-Yi Ren, Xiao-Hui Lyu, Yan Ding, Fang Suo, Guang-Can Shao, Jun Li and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Evolutionary persistence and divergence of thebioRxiv : the preprint server for biology · 2025
    Article
  3. Killer meiotic drive executed by two alternative conformations of a single protein.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yu Hua *National Institute of Biological Sciences, Beijing 102206, China.
Jianxiu Zhang *Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-1864-7510
Man-Yun Yang *National Institute of Biological Sciences, Beijing 102206, China.
Fan-Yi Zhang *National Institute of Biological Sciences, Beijing 102206, China.
Jing-Yi RenNational Institute of Biological Sciences, Beijing 102206, China.
Xiao-Hui LyuNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0009-0007-4684-5710
Yan DingNational Institute of Biological Sciences, Beijing 102206, China.
Fang SuoNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0000-0001-6526-5489
Guang-Can ShaoNational Institute of Biological Sciences, Beijing 102206, China.
Jun LiNational Institute of Biological Sciences, Beijing 102206, China.
Meng-Qiu DongNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0000-0002-6094-1182
Keqiong YeKey Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0001-6169-7049
Li-Lin DuNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0000-0002-1028-7397

Funding

MOST | National Key Research and Development Program of China (NKPs) 2017YFA0504600MOST | National Natural Science Foundation of China (NSFC) 31900405
6 · The paper itself

Abstract

Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing meiotic products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of them have been characterized at the molecular level, and their killing mechanisms remain largely unknown. In this study, we identify that a gene previously deemed essential for cell survival in the fission yeast

Indexed as

Epigenesis, GeneticMeiosisMitosisSchizosaccharomycesSchizosaccharomyces pombe ProteinsHaplotypesSchizosaccharomyces pombe Proteinschromosome segregationcryo-EM structureepigenetic readerkiller meiotic driverresistant haplotype

Identifiers

PMID39485795
PMCPMC11551393

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.