ArticleCell genomics2024
Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.
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Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
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29 citing papers in PubMed.
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- Variation and selection at predicted G-quadruplexes across the human pangenome.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the genetic landscape and admixture dynamics of urban populations across Peru.Communications biology · 2026Article
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- hmmibd-rs: an enhanced hmmIBD implementation for parallelizable identity-by-descent detection from large-scale Plasmodium genomic data.Malaria journal · 2026Article
- Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.NPJ Parkinson's disease · 2026Article
- Strategies in Global Ancestry and Local Ancestry Inference.Current protocols · 2026Article
- Host Immunogenetic Profile Modulates Susceptibility to Apical Periodontitis in a Colombian Population.Current issues in molecular biology · 2026Article
- Advancing personalised and precision nutrition.Journal of nutritional science · 2026Review
- Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes.Frontiers in endocrinology · 2026Article
- High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras.Genomics, proteomics & bioinformatics · 2025Review
- Spectrum and Clinical Interpretation ofInternational journal of molecular sciences · 2025Article
- Evolution of hepatology practice in Mexico and Latin America: From biochemical markers to genomic medicine.World journal of hepatology · 2025Review
- Genetic Variability in Child Growth Among South American Populations: A Perspective Integrating Population Genetics, Growth Standards, and Precision Growth Medicine.International journal of molecular sciences · 2025Review
- ThemedRxiv : the preprint server for health sciences · 2025Article
- Distribution of CCR5-Δ32 and HLA-B*57:01 alleles in HIV-seropositive and HIV-exposed seronegative Peruvian individuals.Human genome variation · 2025Article
- Subcontinental genetic variation in the All of Us Research Program: Implications for biomedical research.American journal of human genetics · 2025Article
- Article
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Authors and funding
78 authors.
Victor BordaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; University of Maryland Institute for Health Computing, University of Maryland School of Medicine, North Bethesda, MD 20852, USA. Electronic address: vicbp1@gmail.com.
Douglas P LoeschInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Bing GuoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Roland LaboulayeInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Diego Veliz-OtaniInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jennifer N FrenchInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Thiago Peixoto LealLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Sunday IkpeInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mateus H GouveiaCenter for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Marla MendesDepartment of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Gonçalo R AbecasisDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Isabela AlvimDepartment of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Carlos E Arboleda-BustosNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Gonzalo ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Humberto ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Mauricio L BarretoInstituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA 40110-040, Brazil.
Lucas BarwickLTRC Data Coordinating Center, The Emmes Company, Rockville, MD, USA.
Marcos A BezzeraDepartment of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife, PE 50670-901, Brazil.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Vanderci BorgesMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Omar CaceresInstituto Nacional de Salud, Lima, Peru; Facultad de Ciencias de la Salud, Universidad Científica del Sur, Lima, Peru.
Jianwen CaiDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Pedro Chana-CuevasCETRAM, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile.
Zhanghua ChenKeck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA, USA.
Brian CusterVitalant Research Institute, San Francisco, CA, USA.
Michael DeanLaboratory of Genomic Diversity, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Carla DinardoInstituto de Medicina Tropical, University of São Paulo, São Paulo, Brazil.
Igor DomingosDepartment of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife, PE 50670-901, Brazil.
Ravindranath DuggiralaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Elena DieguezNeurology Institute, Universidad de la República, Montevideo, Uruguay.
Willian FernandezNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Henrique B FerrazMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Frank GillilandKeck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA, USA.
Heinner GuioInstituto Nacional de Salud, Lima, Peru; INBIOMEDIC Research Center, Lima, Peru; Universidad de Huánuco, Huánuco, Peru.
Bernardo HortaFaculdade de Medicina, Departamento de Medicina Social, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Jill M JohnsenBloodworks Northwest Research Institute, Seattle, WA, USA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Shannon KellyVitalant Research Institute, San Francisco, CA, USA; UCSF Benioff Children's Hospital, University of California, San Francisco, Oakland, CA, USA.
Eimear E KennyIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Barbara A KonkleDepartment of Medicine, University of Washington, Seattle, WA, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Andres LescanoNeurology Institute, Universidad de la República, Montevideo, Uruguay.
M Fernanda Lima-CostaInstituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Deborah A MeyersDivision of Genetics, Genomics, and Precision Medicine, University of Arizona, Tucson, AZ, USA.
Michel S NaslavskyHuman Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carlos PadillaInstituto Nacional de Salud, Lima, Peru.
Michael PreussIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Victor RaggioGenetics Department, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Alexander P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Carlos R RiederDepartamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, and The Evelyn F. McKnight Brain Institute, University of Miami, Miami, FL, USA.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, and The Evelyn F. McKnight Brain Institute, University of Miami, Miami, FL, USA.
Cesar SanchezInstituto Nacional de Salud, Lima, Peru.
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bruno Lopes Santos-LobatoInstituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil.
Artur Francisco Schumacher-SchuhDepartamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Marilia O ScliarHuman Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil.
Edwin K SilvermanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Jessica Lasky-SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Vitor TumasRibeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD)
National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN) Consortium
Trans-Omics for Precision Medicine (TOPMed) Population Genetics Working Group
Ignacio F MataUniversity of Maryland Institute for Health Computing, University of Maryland School of Medicine, North Bethesda, MD 20852, USA.
Ryan D HernandezInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Eduardo Tarazona-SantosDepartment of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia, Lima, Peru.
Timothy D O'ConnorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Health Equity and Population Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program in Personalized Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: timothydoconnor@gmail.com.
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MThe Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MVascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7MWhole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD RiskR01HL113323 · NHLBI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BLANGERO, JOHN, CURRAN, JOANNE E. · 2012 to 2016
$8.2MRESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MModeling the impact of Women's Specific Health Factors in PD outcomes in LatinasR01NS112499 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FERNANDEZ MATA, IGNACIO · 2020 to 2024
$3.3MGenetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0MNHGRI NIH HHS R35 HG010692NHGRI NIH HHS U54 HG003067NHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201500015CNHLBI NIH HHS HHSN268201500016CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113323NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R37 HL066289NHLBI NIH HHS T32 HL007698NHLBI NIH HHS U01 HL120393NIA NIH HHS T32 AG000262NIBIB NIH HHS R01 EB015611NIEHS NIH HHS HHSN268201600032CNIEHS NIH HHS HHSN268201600033CNIGMS NIH HHS R01 GM142112NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS R01 NS112499NINDS NIH HHS R56 NS029993
Abstract
Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing summary statistics (i.e., allele and haplotype frequencies) without transferring individual-level genotypes. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic software in the presence of admixture. By providing this resource, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people.
Indexed as
Genetics, PopulationAlgorithmsGenetic VariationGenome-Wide Association StudyHaplotypesHumansLatin AmericaSoftwareGLAD-matchGWASidentity-by-descentimputationLatin Americalocal ancestrymigrationpopulation structure
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