Evidence map›Paper›PMID 39487510›Full record

ArticleBMC chemistry2024

Bioassay-guided isolation and in Silico characterization of cytotoxic compounds from Hemimycale sp. Sponge targeting A549 lung cancer cells.

Asmaa Abo Elgoud Said, Islam M Abdel-Rahman, Yaser A Mostafa, Eman Zekry Attia, Mamdouh Nabil Samy, Usama Ramadan Abdelmohsen, Katsuyoshi Matsunami, Mostafa A Fouad, Yaser G Gouda

Abstract read
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In one paragraph

Article in BMC chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Marine natural products.Natural product reports · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Asmaa Abo Elgoud SaidDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Islam M Abdel-RahmanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New-Minia, 61111, Egypt.
Yaser A MostafaPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Eman Zekry AttiaDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Mamdouh Nabil SamyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. usama.ramadan@mu.edu.eg.
Katsuyoshi MatsunamiGraduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Mostafa A FouadDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Yaser G GoudaDepartment of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioassay-guided fractionation approach led to identification of two novel compounds; (4-(hydroxymethyl)-3-methoxy-1H-pyrazol (1) and mycalene (2), alongside with four known metabolites; octadecane (3), hexatriacontane (4), 1-heneicosanol (5) and heptatriacontanoic acid (6) from the Red Sea marine sponge Hemimycale sp. The ethyl acetate fraction showed a noticeable cytotoxic activity against the lung cancer cell line (A549) with IC

Indexed as

CytotoxicityHemimycaleIn silicoMarine spongeNMRRed sea

Identifiers

PMID39487510
PMCPMC11531136

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.