Evidence map›Paper›PMID 39487603›Full record

ArticleEuropean journal of clinical investigation2025

Glycolytic activity following anti-CD19 CAR-T cell infusion in non-Hodgkin lymphoma.

Nicolas Vallet, Laurianne Drieu Larochelle, Maria-Joao Santiago-Ribeiro, Alban Villate, Martin Eloit, Arnaud Cirée, Laura Zaragoza, Virginie André, Marie Prat-Lepesant, Olivier Hérault and 3 more

Abstract read
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In one paragraph

Article in European journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicolas ValletHematology and Cell Therapy, University Hospital Tours, Tours, France.ORCID https://orcid.org/0000-0001-9568-3358
Laurianne Drieu LarochelleHematology and Cell Therapy, University Hospital Tours, Tours, France.
Maria-Joao Santiago-RibeiroDepartment Imaging Nuclear Medicine, University Hospital Tours, Tours, France.
Alban VillateHematology and Cell Therapy, University Hospital Tours, Tours, France.
Martin EloitHematology and Cell Therapy, University Hospital Tours, Tours, France.
Arnaud CiréeDepartment of Biological Immunology, University Hospital Tours, Tours, France.
Laura ZaragozaDepartment of Pharmacy, University Hospital Tours, Tours, France.
Virginie AndréDepartment of Pharmacy, University Hospital Tours, Tours, France.
Marie Prat-LepesantEtablissement Français du Sang, Tours, France.
Olivier HéraultInserm U1069 N2COx, University of Tours, Tours, France.
Flavie ArbionDepartment of Pathology, University Hospital Tours, Tours, France.
Hélène BlascoDepartment of Biochemistry, University Hospital Tours, Tours, France.
Emmanuel GyanHematology and Cell Therapy, University Hospital Tours, Tours, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lactate in the first weeks post-CAR-T infusion. In 17 patients treated with CD28 harbording anti-CD19 CAR-T for relapsed/refractory non-Hodgkin lymphomas, PB lactate levels increased following CAR-T infusion. Elevated lactate levels correlated with longer CAR-T persistence and higher CD8+/CD4+ ratio. Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring.

Indexed as

Antigens, CD19GlycolysisImmunotherapy, AdoptiveLactic AcidLymphoma, Non-HodgkinReceptors, Chimeric AntigenAdultAgedFemaleHumansMaleMiddle AgedAntigens, CD19Lactic AcidReceptors, Chimeric AntigenCAR‐T cellscell therapymetabolismNHLT cells

Identifiers

PMID39487603
PMCPMC11744912

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.