Evidence map›Paper›PMID 39487653›Full record

Trial reportJournal of the International Society of Sports Nutrition2024

Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study.

Haotian Zhao, Hongkang Zhu, Hezhang Yun, Jingqi Liu, Ge Song, Jin Teng, Dixin Zou, Naiyan Lu, Chang Liu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haotian ZhaoJiangnan University, Department of physical education, Wuxi, China.
Hongkang ZhuJiangnan University, School of Food Science and Technology, Wuxi, China.
Hezhang YunBeijing Sport University, School of Sport Science, Beijing, China.
Jingqi LiuBeijing Sport University, School of Sport Science, Beijing, China.
Ge SongBeijing Sport University, School of Sport Science, Beijing, China.
Jin TengBeijing Sport University, School of Sport Science, Beijing, China.
Dixin ZouChina Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, Beijing, China.
Naiyan LuJiangnan University, School of Food Science and Technology, Wuxi, China.
Chang LiuBeijing Sport University, School of Sport Science, Beijing, China.ORCID 0000-0002-7867-6807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the impact of Urolithin A (UA) on muscle endurance, muscle strength, inflammatory levels, oxidative stress, and protein metabolism status in resistance-trained male athletes.

methodAn 8-week randomized, double-blind, placebo-controlled study was conducted with twenty resistance-trained male athletes. Participants were supplemented with 1 g of UA daily. Muscle strength and muscle endurance measures were assessed, and fasting venous blood samples and morning urine samples were collected to evaluate their oxidative stress levels, inflammatory markers, and protein metabolism status.

resultsThere were no significant differences observed in terms of dietary energy intake and composition between the two assessments conducted within a 24-hour period. After 8 weeks of UA supplementation, compared to baseline measurements, the UA group exhibited increases in 1RM bench press and squat, although these changes were not statistically significant (Δ = 3.00 ± 0.17 kg,

conclusionsAfter 8 weeks of UA supplementation at 1 g/day, resistance-trained male athletes showed improvements in muscle strength and endurance. Additionally, UA supplementation was also associated with reduced oxidative stress levels and a decrease in inflammation response levels.

Indexed as

CoumarinsDietary SupplementsMuscle StrengthOxidative StressPhysical EnduranceResistance TrainingAdultBiomarkersDouble-Blind MethodHumansInflammationMaleMuscle, SkeletalSports Nutritional Physiological PhenomenaYoung Adult3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneBiomarkersCoumarinsergogenic aidexercise performanceoxidative stressUrolithin A

Identifiers

PMID39487653
PMCPMC11536656

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.