Evidence map›Paper›PMID 39488626›Full record

ArticleGenes and immunity2024

Myeloid derived suppressor cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection.

Ido Nachmany, Shir Nevo, Sarit Edelheit, Avital Sarusi-Portuguez, Gilgi Friedlander, Tomer-Meir Salame, Vera Pavlov, Oran Yakubovsky, Niv Pencovich

Abstract read
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026
    Pooled it
  2. EREG-secreting THBS1Hepatobiliary surgery and nutrition · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ido Nachmany *The Laboratory of Molecular Biology, Department of Surgery and Transplantation, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine and Medical Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Shir Nevo *The Laboratory of Molecular Biology, Department of Surgery and Transplantation, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine and Medical Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Sarit EdelheitThe Laboratory of Molecular Biology, Department of Surgery and Transplantation, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine and Medical Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Avital Sarusi-PortuguezThe Mantoux Bioinformatics institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.
Gilgi FriedlanderThe Mantoux Bioinformatics institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-8513-1998
Tomer-Meir SalameMass Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Vera PavlovThe Laboratory of Molecular Biology, Department of Surgery and Transplantation, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine and Medical Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Oran YakubovskyThe Laboratory of Molecular Biology, Department of Surgery and Transplantation, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine and Medical Sciences, Tel-Aviv University, Tel-Aviv, Israel.ORCID 0000-0002-8849-6615
Niv PencovichThe Laboratory of Molecular Biology, Department of Surgery and Transplantation, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine and Medical Sciences, Tel-Aviv University, Tel-Aviv, Israel. niv.pencovich@sheba.health.gov.il.ORCID 0000-0002-0049-0295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver regeneration following resection is a complex process relying on coordinated pathways and cell types in the remnant organ. Myeloid-Derived Suppressor Cells (MDSCs) have a role in liver regeneration-related angiogenesis but other roles they may play in this process remain to be elucidated. In this study, we sought to examine the effect of G-MDSCs on hepatocytes proliferation and immune modulation during liver regeneration. Global gene expression profiling of regenerating hepatocytes in mice with CD11b

Indexed as

Cell ProliferationHepatocytesLiver RegenerationMyeloid-Derived Suppressor CellsAnimalsHepatectomyLiverMaleMiceMice, Inbred C57BL

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.