ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025
Functional Brain Connectivity Predictors of Prospective Substance Use Initiation and Their Environmental Correlates.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Cognitive and affective neurodevelopment in youth exposed to deprivation and threat.bioRxiv : the preprint server for biology · 2026Article
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neighborhood air pollution is associated with attenuated neurocognitive maturation over early adolescence.Developmental cognitive neuroscience · 2026Article
- Connectome-based predictive modeling of concurrent and longitudinal substance use vulnerability in adolescence.Developmental cognitive neuroscience · 2026Article
- Connectome-based prediction of problematic use of social media in adolescents: Findings from the ABCD study.NeuroImage · 2026Article
- Environmental, Health, and Psychological Factors Predict Alcohol Sipping in Childhood: A Machine Learning Analysis of the ABCD Study.JAACAP open · 2025Article
- GLP-1 Agonists for Pediatric Psychopharmacology: Opportunities and Cautions.Clinical and translational science · 2025Article
- Resting-State Sensory-Motor Connectivity between Hand and Mouth as a Neural Marker of Socioeconomic Disadvantage, Psychosocial Stress, Cognitive Difficulties, Impulsivity, Depression, and Substance Use in Children.Journal of cellular neuroscience · 2025Article
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Abstract
backgroundEarly substance use initiation (SUI) places youth at substantially higher risk for later substance use disorders. Furthermore, adolescence is a critical period for the maturation of brain networks, the pace and magnitude of which are susceptible to environmental influences and may shape risk for SUI.
methodsWe examined whether patterns of functional brain connectivity during rest (rsFC), measured longitudinally during pre- and early adolescence, can predict future SUI. Next, in an independent subsample, we tested whether these patterns were associated with earlier environmental exposures, specifically neighborhood pollution and socioeconomic dimensions. We utilized data from the ABCD (Adolescent Brain Cognitive Development) Study. SUI was defined as first-time use of at least 1 full dose of alcohol, nicotine, cannabis, or other drugs. We created a control group (n = 228) of participants without SUI who were matched to the SUI group (n = 233) on age, sex, race/ethnicity, household income, and parental education.
resultsMultivariate analysis showed that whole-brain rsFC from 9-10 to 11-12 years of age (prior to SUI) prospectively differentiated the SUI and control groups. The SUI-related rsFC pattern was also related to aging in both groups, suggesting a pattern of accelerated maturation in the years prior to SUI. This same pattern of rsFC was predicted by higher pollution but not neighborhood disadvantage (adjusted for family socioeconomic factors) in an independent subsample (n = 2854).
conclusionsBrain functional connectivity patterns in early adolescence that are linked to accelerated maturation can predict SUI in youth and are associated with exposure to pollution.
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