Evidence map›Paper›PMID 39490795›Full record

ArticleThe American journal of clinical nutrition2025

Blood biomarkers of trans-fatty acid intake among Nigerian adults in the Federal Capital Territory: a cross-sectional study.

Matti Marklund, Soji Billyrose, Ikechukwu A Orji, Mercy U Ikechukwu-Orji, Clementina Okoro, Chijioke Obagha, Guhan Iyer, Erica L Jamro, Adedayo Ojo, William S Harris and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matti MarklundCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, United States; The George Institute for Global Health, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia; Clinical Nutrition and Metabolism Unit, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. Electronic address: mmarklu1@jhu.edu.
Soji BillyroseCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Ikechukwu A OrjiCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Mercy U Ikechukwu-OrjiCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Clementina OkoroCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Chijioke ObaghaCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Guhan IyerCardiovascular Division and Global Health Center, Washington University in St. Louis, St. Louis, MO, United States.
Erica L JamroCardiovascular Division and Global Health Center, Washington University in St. Louis, St. Louis, MO, United States.
Adedayo OjoCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria; Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, The Netherlands.
William S HarrisFatty Acid Research Institute, Sioux Falls, SD, United States; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States.
Jason Hy WuThe George Institute for Global Health, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia; School of Population Health, UNSW Sydney, Sydney, NSW, Australia.
Lisa R HirschhornDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Robert J Havey Institute for Global Health, Northwestern University, Chicago, IL, United States.
Linda Van HornDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Mark D HuffmanThe George Institute for Global Health, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia; Cardiovascular Division and Global Health Center, Washington University in St. Louis, St. Louis, MO, United States; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Dike B OjjiCardiovascular Research Unit, University of Abuja, and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria; Department of Internal Medicine, Faculty of Clinical Sciences, University of Abuja, Abuja, Nigeria.

Funding

Evaluating the Implementation and Scale-Up of Nigeria National Sodium Reduction ProgramUH3HL152381 · NHLBI · UNIVERSITY OF ABUJA · PI HUFFMAN, MARK D, OJJI, DIKE BEVIS · 2022 to 2025
$3.5M
NHLBI NIH HHS UH3 HL152381
6 · The paper itself

Abstract

backgroundIntake of trans-fatty acids (TFAs) is an established risk factor for cardiovascular disease. In April 2023, Nigeria passed regulations limiting TFA content in foods, fats, and oils, but the current level of TFA exposure in the Nigerian population is unknown.

objectivesTo quantify trans-fatty acid (TFA) biomarkers in dried blood spots from Nigerian adults in the Federal Capital Territory before policy enforcement, establish baseline levels for future evaluations, assess subgroup variations by demographic and socioeconomic factors, and compare TFA levels with data from 30 countries worldwide.

methodsWe used gas chromatography to measure TFA content in dried blood spots from adults participating in a cross-sectional household survey using a representative sampling frame. Individual TFA (t-16:1, t-18:1, and t- 18:2) and their total were expressed as percentage of total fatty acids. We assessed differences in TFA levels between subgroups based on sex, age, body mass index (BMI), education, income, and local government area using multivariable-adjusted linear regression models. Mean TFA levels were compared with samples from individuals in 30 countries.

resultsIn 213 adults (62% females; mean age: 36 y, mean BMI: 25.9 kg/m

conclusionsThese results provide a baseline assessment of TFA exposure in Nigerian adults to evaluate implementation and effect of national regulation passed in 2023. The observed subgroup differences may help identify subpopulations for targeted interventions to reduce TFA intake.

Indexed as

BiomarkersTrans Fatty AcidsAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedNigeriaYoung AdultBiomarkersTrans Fatty AcidsAfricadietary assessmentdietary biomarkerfood policymiddle-income countriesnutritional statussurveytrans-fat

Identifiers

PMID39490795
PMCPMC11747188

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.