Evidence map›Paper›PMID 39491022›Full record

ArticleCardiovascular ultrasound2024

Left atrial function during exercise stress echocardiography as a sign of paroxysmal/persistent atrial fibrillation.

Angela Zagatina, Quirino Ciampi, Jesus Vazquez Peteiro, Elena Kalinina, Irina Begidova, Ratnasari Padang, Alla Boshchenko, Elisa Merli, Matteo Lisi, Hugo Rodriguez-Zanella and 16 more

Abstract readMulticenter Study
In one paragraph

Article in Cardiovascular ultrasound, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Angela ZagatinaCardiology Department, Research Cardiocenter "Medika", St. Petersburg, Russian Federation. zag_angel@yahoo.com.
Quirino CiampiFatebenefratelli Hospital of Benevento, Benevento, Italy.
Jesus Vazquez PeteiroCHUAC- Complexo Hospitalario Universitario A Coruna- University of A Coruna, La Coruna, Spain.
Elena KalininaCardiology Department, Research Cardiocenter "Medika", St. Petersburg, Russian Federation.
Irina BegidovaCardiology Department, Research Cardiocenter "Medika", St. Petersburg, Russian Federation.
Ratnasari PadangDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Alla BoshchenkoCardiology Research Institute, Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation.
Elisa MerliCardiology Unit, Ospedale Per Gli Infermi, Faenza, Italy.
Matteo LisiDepartment of Cardiovascular Disease, Division of Cardiology, AUSL Romagna, Ospedale S. Maria Delle Croci, Ravenna, Italy.
Hugo Rodriguez-ZanellaInstituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico.
Sergio KobalEchocardiography Unit, Soroka University Medical Center, Be'er Sheva, Israel.
Gergely AgostonInstitute of Family Medicine, University of Szeged, Szeged, Hungary.
Albert VargaInstitute of Family Medicine, University of Szeged, Szeged, Hungary.
Karina Wierzbowska-DrabikDepartment of Internal Disease and Clinical Pharmacology, Medical University, Lodz, Poland.
Jarosław D KasprzakFirst Department and Chair of Cardiology, Medical University of Lodz, Bieganski Specialty Hospital, Lodz, Poland.
Rosina ArbucciInvestigaciones Medicas, Buenos Aires, Argentina.
Olga ZhuravlevaCardiology Research Institute, Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation.
Jelena ČelutkienėCentre of Cardiology and Angiology, Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Centre of Innovative Medicine, Vilnius, Lithuania.
Jorge LowensteinInvestigaciones Medicas, Buenos Aires, Argentina.
Nithima Chaowalit RatanasitDivision of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Paolo ColonnaDepartment of Cardiology, Policlinico Hospital, Bari, Italy.
Scipione CarerjDivisione Di Cardiologia, Policlinico UniversitarioUniversità Di Messina, Messina, Italy.
Mauro PepiCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Patricia A PellikkaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Eugenio PicanoCardiology Clinic, University Center Serbia, Medical School, University of Belgrade, Belgrade, Serbia.
Stress Echo 2030 study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAtrial cardiomyopathy is closely associated with atrial fibrillation (AF), and some patients exhibit no dysfunction at rest but demonstrate evident changes in left atrial (LA) function and LA volume during exercise. This study aimed to identify distinguishing signs during exercise stress echocardiography (ESE) among patients in sinus rhythm (SR), with and without history of paroxysmal/persistent AF (PAF).

methodsA prospective cohort of 1055 patients in SR was enrolled across 12 centers. The main study cohort was divided into two groups: the modeling group (n = 513) and the verification group (n = 542). All patients underwent ESE, which included B-lines, LA volume index (LAVi), and LA strain of the reservoir phase (LASr).

resultsAge, resting and stress LAVi and LASr, and B-lines were identified as a combination of detectors for PAF in both groups. In the entire cohort, aside from resting and stress LAVi and LASr, additional parameters differentiating PAF and non-PAF patients were the presence of systemic hypertension, exercise E/e' > 7, worse right ventricle (RV) contraction during exercise (∆ tricuspid annular plane systolic excursion < 5 mm), a lower left ventricular contractile reserve (< 1.6), and a reduced chronotropic reserve (heart rate reserve < 1.64). The composite score, summing all 9 items, yielded a score of > 4 as the best sensitivity (79%) and specificity (65%).

conclusionESE can complement rest echocardiography in the identification of previous PAF in patients with SR through the evaluation of LA functional reservoir and volume reserve, LV chronotropic, diastolic, and systolic reserve, and RV contractile reserve.

Indexed as

Atrial FibrillationAtrial Function, LeftEchocardiography, StressExercise TestHeart AtriaAgedFemaleHumansMaleMiddle AgedProspective StudiesAtrial fibrillationB-linesExercise stress echoLeft atriumReservoir strain

Identifiers

PMID39491022
PMCPMC11533336

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.