ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Adults with Down syndrome and obstructive sleep apnea treated with hypoglossal nerve stimulation.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Caregivers' Perspectives on Medical Management and Its Helpfulness in Down Syndrome.American journal of medical genetics. Part A · 2026Article
- The Occurrence of Obstructive Sleep Apnea and Its Association With Alzheimer Dementia in Medicaid-Enrolled Adults With Down Syndrome, 2011-2019.American journal of medical genetics. Part A · 2026Article
- Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea and Comorbid Neuromuscular Disorders.The Laryngoscope · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesWe aimed to examine the feasibility, adherence to therapy, and efficacy of hypoglossal nerve stimulation in adults with Down syndrome and obstructive sleep apnea.
methodsAdults patients with Down syndrome who met criteria for hypoglossal nerve stimulation were prospectively enrolled. Objective adherence was extracted from a cloud-based compliance database. Preoperative sleep studies were compared to follow-up testing performed no sooner than 3 months after device activation.
resultsEleven adults with Down syndrome underwent implantation of hypoglossal nerve stimulation between May 2021 and July 2024. Median age was 27 years (interquartile range 26, 33), body mass index 28.5 kg/m
conclusionsIn this small initial cohort, hypoglossal nerve stimulation appears to be a safe, well-tolerated, and efficacious treatment option for adults with Down syndrome with moderate-to-severe obstructive sleep apnea and positive airway pressure therapy intolerance. CITATION: Huyett P, Santoro SL, Oreskovic NM, Skotko BG. Adults with Down syndrome and obstructive sleep apnea treated with hypoglossal nerve stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.