Evidence map›Paper›PMID 39494450›Full record

Trial reportOpen forum infectious diseases2024

High Prescription Rate of Medications With Rifampin Drug-drug Interactions in Patients With Diabetic Foot Osteomyelitis: Should Rifabutin Be Included in Clinical Trials for Adjunctive Therapy?

Christina Mallarino-Haeger, Allison Watson, Umnia Mahgoub, Lily Francis, Maryam Heydari, Muaaz Choudhary, Manuel Garcia-Toca, Manish Patel, Russell R Kempker, Maya Fayfman and 1 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina Mallarino-HaegerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Allison WatsonDepartment of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-2207-9971
Umnia MahgoubDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-8482-8504
Lily FrancisMedical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-5460-8279
Maryam HeydariDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0007-3379-4846
Muaaz ChoudharyLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Manuel Garcia-TocaDivision of Vascular Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Manish PatelGrady Health System, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1372-9696
Russell R KempkerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-7188-4996
Maya FayfmanGrady Health System, Atlanta, Georgia, USA.
Marcos C SchechterDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-6165-7423

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
NIAID NIH HHS P30 AI168386
6 · The paper itself

Abstract

Rifampin may improve diabetic foot osteomyelitis outcomes, but its extensive drug-drug interactions could hamper its use. Here, through a review of the medications prescribed to a cohort of 190 persons with diabetic foot osteomyelitis, we show that rifabutin, a rifamycin with fewer drug-drug interactions, would be easier to implement in practice.

Indexed as

diabetic foot osteomyelitisdrug-drug interactionsrifamycins

Identifiers

PMID39494450
PMCPMC11530956

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.