ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025
Switch to Integrase Strand Transfer Inhibitors During the Menopausal Transition Is Associated With Accelerated Body Composition Change in Women With HIV.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Initiation of dolutegravir vs efavirenz on 12- and 24-month weight, body mass index, blood pressure, and incident hypertension: A target trial emulation.Annals of epidemiology · 2026Trial
- Article
- Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE.The lancet. HIV · 2026Article
- Perimenopause as an obesogenic sensitive period: Contributions to elevated cardiovascular risk.American journal of preventive cardiology · 2026Article
- Menopause is associated with faster increases in insulin resistance in women with HIV.AIDS (London, England) · 2026Article
- Menopause: an opportunity to optimize health and well being for people with HIV.Current opinion in HIV and AIDS · 2025Review
- Weight loss with real-world doravirine use in the OPERA cohort: a US-based cohort study.AIDS research and therapy · 2025Article
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16 authors.
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Abstract
backgroundIntegrase strand transfer inhibitors (INSTIs) and the menopausal transition have been associated with body composition changes in women with human immunodeficiency virus (WWH), but their interaction is unknown.
methodsFrom 2006 to 2019, 1131 virally-suppressed WWH (419 who switched to INSTI [INSTI+]; 712 who did not switch [INSTI-]) and 887 women without HIV (WWOH) from the Women's Interagency HIV Study were included. Mixed-effects models were used to evaluate change in waist circumference (WC) and body mass index (BMI) by menopausal phase defined using anti-Müllerian hormone, a biomarker of ovarian reserve.
resultsDuring premenopause, WWH had increases in WC (INSTI+: 0.01 cm per 6 months [95% confidence interval {CI}: -.29 to .32] and INSTI-: 0.22 cm per 6 months [95% CI: -.01 to .44]) that were not statistically significantly different from WWOH; there was also little difference by INSTI status. In late perimenopause, INSTI+ had faster increases in WC (0.37 cm per 6 months [95% CI: .15-.60]) while INSTI- had smaller increases (0.14 cm per 6 months [95% CI: -.06 to .34]) compared to WWOH. In menopause, INSTI+ had faster increases, peaking at 43 months then declining, while INSTI- had smaller increases (0.14 cm per 6 months [95% CI: -.02 to .30]). Compared to INSTI-, in late perimenopause, INSTI+ had 0.26 cm per 6 months (95% CI: .02-.50) faster linear increases in WC and in menopause, INSTI+ was associated with faster increases, peaking at 41 months.
conclusionsSwitching to an INSTI-based regimen during late perimenopause and menopause is associated with faster increases in WC when compared to women who did not switch. Menopausal status should be considered when switching to an INSTI.
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