Evidence map›Paper›PMID 39496639›Full record

ArticleScientific reports2024

KRAS G12C mutation in NSCLC in a small genetic center: insights into sotorasib therapy response potential.

Metin Eser, Gulam Hekimoglu, Murat Hakki Yarar, Sezin Canbek, Melike Ozcelik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Genomic insights on lung cancer risk: identifying new variants in Amazonian indigenous populations.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Metin EserDepartment of Medical Genetics, Umraniye Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-7118-7958
Gulam HekimogluDepartment of Histology and Embryology, Hamidiye International Faculty of Medicine, University of Health Sciences, Istanbul, Turkey. gulam.hekimoglu@sbu.edu.tr.ORCID http://orcid.org/0000-0002-5027-6756
Murat Hakki YararDepartment of Medical Genetics, Umraniye Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-8481-9803
Sezin CanbekDepartment of Medical Genetics, Umraniye Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-9516-0047
Melike OzcelikDepartment of Medical Oncology, Umraniye Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-0406-715X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer remains a significant health challenge, characterized by aberrant tissue growth within the pulmonary system. Early carcinogenic events often involve genomic instability and the emergence of a mutator phenotype. In this study, we aimed to explore the mutator phenotype in 89 patients diagnosed with non-small-cell lung cancer (NSCLC). RNA isolation from formalin-fixed paraffin-embedded (FFPE) tissue samples was performed using the Promega ReliaPrep RNA Miniprep System, facilitating gene amplification relevant to cancer through the Archer

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsMutationProto-Oncogene Proteins p21(ras)AdultAgedAged, 80 and overFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedPiperazinesPyridinesPyrimidinesKRAS protein, humanPiperazinesProto-Oncogene Proteins p21(ras)PyridinesPyrimidinessotorasibKRAS G12C mutationNon-small-cell lung cancerSotorasib

Identifiers

PMID39496639
PMCPMC11535051

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.